New Ebola trial vaccine 'safe', researchers report
But while it triggered an antibody response in test subjects, further trials must be held to establish whether the drug actually protects against Ebola, they said.
Dubbed Ad5-EBOV, the vaccine is the first based on the strain of the Ebola virus behind the west African outbreak, according to a paper published in The Lancet medical journal.
"Up to now, all tested Ebola virus vaccines have been based on the virus strain from the Zaire outbreak in 1976"—the first recorded.
The Phase I trial tested the safety of the drug in 120 people in China's Jiangsu province in December and January, said the study authors from a variety of research institutions, public health bodies and the Tianjin CanSino Biotechnology company.
People were given a low or high dose of the test vaccine, or a placebo.
The researchers then monitored them over 28 days for any side-effects and an immune response through the activation of so-called T-cell infection-fighting white blood cells.
They witnessed "no serious adverse events", the researchers said, and antibodies were "significantly increased in participants".
This showed the drug "has some potential", the team said, though it was not known whether the immune response lasted beyond 28 days, or whether a booster shot would be needed.
There is no licensed vaccine against the disease which has killed more than 10,000 people in west Africa out of nearly 25,000 infected since the start of 2014, mainly in Liberia, Sierra Leone and Guinea.
The UN's World Health Organization gave the green light last August for experimental drugs to be used in the outbreak, and several candidates are being fast-tracked through the normally years-long trial process.
Many are much further advanced than Ad5-EBOV, having already reached the Phase III testing phase in hard-hit countries, where they are being administered to people at risk of infection.
Health officials say the current outbreak has been brought under control, but not yet eradicated.
© 2015 AFP