Faulty modeling studies led to overstated predictions of Ebola outbreak

The Ebola virus, isolated in November 2014 from patient blood samples obtained in Mali. The virus was isolated on Vero cells in a BSL-4 suite at Rocky Mountain Laboratories. Credit: NIAID

Frequently used approaches to understanding and forecasting emerging epidemics—including the West African Ebola outbreak—can lead to big errors that mask their own presence, according to a University of Michigan ecologist and his colleagues.

"In the early days of the Ebola outbreak, a lot of people got into the forecasting business. They did it using appealingly simple mathematical models, and the result was a series of warnings that alerted the world, quite rightly, to the seriousness of the situation," said Aaron King, an associate professor in the U-M Department of Ecology and Evolutionary Biology.

"But in the end, most of those predictions turned out to be overstated."

On March 23, exactly one year after it announced there was an Ebola outbreak in Guinea, the World Health Organization released a situation update stating that there had been 24,842 Ebola cases, including 10,299 deaths, to date in Sierra Leone, Liberia and Guinea.

Last September, the U.S. Centers for Disease Control and Prevention estimated—based on computer modeling—that Liberia and Sierra Leone could see up to 1.4 million Ebola cases by January 2015 if the viral disease kept spreading without effective methods to contain it. Belatedly, the international community stepped up efforts to control the outbreak, and the explosive growth slowed.

"Those predictions proved to be wrong, and it was not only because of the successful intervention in West Africa," King said. "It's also because the methods people were using to make the forecasts were inappropriate."

In a paper scheduled for online publication March 31 in Proceedings of the Royal Society B, King and his colleagues suggest several straightforward and inexpensive ways to avoid those pitfalls when the next big strikes. Their suggestions pertain to disease transmission models, sophisticated systems of equations that use data from the early stages of an outbreak to predict how it will unfold.

"It's just a matter of time before the next outbreak, and we want to make sure that we know how to provide reliable forecasts to guide the public health response when it happens," King said.

Many of last year's Ebola forecasts were made using common, off-the-shelf transmission models called deterministic models. Such models don't account for the random elements in disease transmission—how many people are infected by each transmission event, for example—and are in incapable of accurately communicating uncertainty.

King and his colleagues say deterministic models should be avoided. So-called stochastic models, which account for randomness and which can more precisely communicate uncertainty, should be used instead.

In addition to using deterministic models, many Ebola forecasters tried to fit those models to the total number of cases that had accumulated since the start of the outbreak. The end result was forecasts that overestimated the eventual size of the Ebola and greatly underestimated the uncertainty in those forecasts, according to King and his colleagues.

"Deterministic models are easier and faster to work with, and the results look really good," King said. "But when you use them, it's a double whammy. Not only are you wrong, you are very sure that you are right."

More information: Avoidable errors in the modeling of outbreaks of emerging pathogens, with special reference to Ebola , rspb.royalsocietypublishing.or … .1098/rspb.2015.0347

Citation: Faulty modeling studies led to overstated predictions of Ebola outbreak (2015, March 31) retrieved 14 July 2024 from https://medicalxpress.com/news/2015-03-faulty-overstated-ebola-outbreak.html
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