Novel nanoparticles could save soldiers' lives after explosions

Novel nanoparticles could save soldiers’ lives after explosions
Soldiers with life-threatening blast wounds might one day benefit from a new nanoparticle under development. Credit: Stocktrek Images/iStock/Thinkstock

Soldiers who suffer internal trauma from explosions might one day benefit from a new treatment now under development. Researchers report in the journal ACS Macro Letters that injecting a certain type of nanoparticle helped reduce lung damage in rats experiencing such trauma. The potential treatment, which could be given at the most critical moment immediately after a blast, could save lives.

Pamela J. VandeVord, Erin B. Lavik and colleagues explain that in today's conflict zones, explosions account for 79 percent of combat-related injuries. Internal bleeding in the lungs resulting from these blasts can lead to death. Soldiers with such injuries need medical attention within a few hours, but options for immediate treatment are lacking. VandeVord's team set out to fill this therapeutic void.

Building on past research in this area, the researchers paired clot-promoting with a corticosteroid that stops inflammation. They injected the particles in rats within 10 minutes of traumatic injury and found the therapeutic compound increased oxygen levels, and reduced and cellular damage in the lungs. The researchers conclude that the nanoparticles could be a good candidate to develop further for emergency trauma care.


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More information: "Steroid-Loaded Hemostatic Nanoparticles Combat Lung Injury after Blast Trauma" ACS Macro Lett., 2015, 4, pp 387–391 DOI: 10.1021/acsmacrolett.5b00061
Journal information: ACS Macro Letters

Citation: Novel nanoparticles could save soldiers' lives after explosions (2015, April 16) retrieved 21 January 2022 from https://medicalxpress.com/news/2015-04-nanoparticles-soldiers-explosions.html
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