Researchers create new combination vaccine to fight Streptococcus A

June 1, 2015
Griffith University Professor Michael Good, of the Institute for Glycomics has developed a groundbreaking combination vaccine that may finally beat Strep A infections. Credit: Griffith University

Griffith University's Institute for Glycomics has developed a groundbreaking, combination vaccine that may finally beat Streptococcus A infections.

Human trials are set to begin, early as next year, for the vaccine which combines the protein, SpyCEP, with a previously developed vaccine J8-DT.

Infections caused by Streptococcus pyogenes are responsible for the deaths of almost 500,000 people worldwide each year. It is particularly prevalent in and Indigenous populations, including Aboriginal people and Torres Strait Islanders.

Infections can range from tonsillitis and what is commonly known as 'schools sores', to life threatening diseases where deep tissues are infected.

If left untreated infections can give rise to the very serious condition of .

Principal Research Leader at the Institute for Glycomics, Professor Michael Good said the team's latest research, which is published in the current issue of the Journal of Immunology, shows that they are getting closer to beating Strep A once and for all.

"We have successfully vaccinated mice with a vaccine that we believe will be suitable for humans," he said.

"We will spend the next six months developing that vaccine at a high level of purity suitable for humans and hope to start a clinical trial next year."

The inspiration to use SpyCEP came to Professor Good during a conference in Rome three years ago. He then thought of combining it with the J8-DT vaccine.

"While Strep A can cause tonsillitis or school sores, it can sometimes develop a mutation in its DNA which causes the organism to spread to other tissues in your body," he said.

"This is when it becomes dangerous and 10-15 per cent of infected people will die when that happens. But we have worked out how to combat that virulence.

"We vaccinated the mice with a protein which induces antibodies that protect the white cells that are needed to battle the when a mutation occurs.

"When the can work, they can attack the organism as long as there are other antibodies there. And this is when the J8-DT vaccine comes in."

Professor Good said it was the combination of the two vaccines that he believes will be highly effective.

Explore further: Human trials for Streptococcus A vaccine

More information: Journal of Immunology, www.jimmunol.org/content/early/2015/05/15/jimmunol.1500157.full.pdf+html

Related Stories

Human trials for Streptococcus A vaccine

February 28, 2013

Griffith University's Institute for Glycomics has launched human trials for a vaccine against Streptococcus A, the germ that causes rheumatic fever.

New hopes for rheumatic fever vaccination

March 19, 2015

A new vaccine to combat the debilitating disease caused by rheumatic fever may soon become a reality, saving hundreds of thousands of deaths from preventable heart disease around the world each year.

Recommended for you

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.