Early detection of highly pathogenic influenza viruses

Lack of appropriate drugs and vaccines during the influenza A virus pandemic in 2009, the recent Ebola epidemic in West Africa, as well as the ongoing Middle Eastern Respiratory Syndrome-Coronavirus outbreak demonstrates that the world is only insufficiently prepared for global attacks of emerging infectious diseases and that the handling of such threats remains a great challenge.

Highly pathogenic avian of the H5N1-type represent one of the most serious threats for the human population. Although the virus has only occasionally been transmitted to humans yet, it results in diseases with a mortality rate of up to 60 percent. There are indications for the H5N1 viruses' mutation towards a more easy transmission to humans. This is especially true for Egypt, which could possibly become a potential epicenter of a new . A better understanding of the molecular basis of the evolution of IAV is therefore of outmost importance for an early detection of highly pathogenic IAV and the efficient fight and control of possible epidemic or even pandemic outbreaks. A multidisciplinary research team, including scholars from the Institute of Medical Virology at Justus Liebig University Giessen, has recently developed a tool, which is suitable to identify candidate pandemic influenza viruses circulating in animal hosts.

On the basis of a combined application of a computational technique (ISM) and experimental molecular virological methods, the research team from Germany and Serbia was able to develop and validate a new tool to predict possible biological effects resulting from naturally occurring mutations as they are found for example in H5N1 viruses in Egypt. Thus, the ISM technique can help to identify those influenza viruses circulating in animal hosts that could efficiently transmit to humans and therewith possess a possible pandemic potential. The research team involves the Institute of Medical Virology (JLU), the Georg-Speyer-Haus—Institute for Tumor Biology and Experimental Therapy (Frankfurt am Main), the Robert-Koch-Institute, Division for HIV and other Retroviruses (Berlin) as well as the Centre for Multidisciplinary Research, Institute of Nuclear Sciences VINCA (Belgrade, Serbia).

In spite of various advances in the last years, there are still substantial gaps regarding the genetic information, epidemiology and pathobiology of H5N1-IAV in humans. "Our data opens the possibility to develop a new tool for the assessment of pandemic risks associated with specific influenza viruses", says Prof. Dr. Stephan Pleschka (Institute of Medical Virology at JLU), leading author of the study. "It could thereby provide a better preparation against potential pandemics. This especially concerns the development of a pre- vaccine, which might add to the prevention of the negative impacts of newly emerging influenza viruses."


Explore further

Scientists 'must not become complacent' when assessing pandemic threat from flu viruses

More information: In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses, Scientific Reports 5, Article number: 11434 DOI: 10.1038/srep11434
Journal information: Scientific Reports

Provided by Justus Liebig University
Citation: Early detection of highly pathogenic influenza viruses (2015, June 25) retrieved 23 August 2019 from https://medicalxpress.com/news/2015-06-early-highly-pathogenic-influenza-viruses.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
11 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more