CFD modeling confirms improved blood flow with new stent design

August 21, 2015, South Dakota State University
This stent graft developed by Sanford Health vascular surgeon Pat Kelly can be deployed inside blood vessels to help patients with thoracoabdominal aneurysms.

Vascular surgeon Pat Kelly of Sanford Health knew his patients were doing better with the stent graft he designed, but he wanted a better understanding of the mechanics before testing the device more widely in a clinical trial. For that, he reached out to SDSU.

Associate professor Stephen Gent in mechanical engineering had done computational fluid dynamics modeling for more than 10 years, but this was his first experience simulating blood flow.

Their research partnership has been a successful one.

The Sanford Health team began a Food and Drug Administration clinic trial on the device in March with the support of data from the computational simulation and the patients Kelly has treated. In April, Sanford Health signed a licensing deal with Medtronic that will bring this life-saving device closer to commercialization. The research was supported by a grant from Sanford Frontiers.

Setting up model

"This is not a trivial problem," Gent said, noting that blood is a pulsed flow. He and graduate student Taylor Suess used a commercially available solver, Star CCM+, and wrote additional code to model blood flow through five stents. Three were commercially available, while two, including Kelly's, were new designs.

First, the researchers had to learn the medical terminology and then link the engineering results with what mattered to the medical professionals."The language overlapped about 60 percent," Gent said, "but it helped that Kelly was a structural engineer before becoming a surgeon."

To compare the devices, Suess had to create a geometrically correct model of each graft relative to the same aorta coordinates and positioning in the body trunk and the arteries that feed the organs and extend into the legs.

"I spent a significant time modifying the CAD files to make the comparison as fair as possible," he pointed out.

Simulating blood flow

Simplified blood flow resembles a liquid moving through pipes from a fluids analysis perspective but, Suess said, "the boundary conditions are intricate and the parameters aren't well-known."

To capture what was happening to blood flow near the artery walls where atherosclerosis tends to begin, the researchers had to write their own code. They had to consider oscillating shear index, time-averaged wall shear stress, relative residence time and wall shear stress temporal gradient.

"The longer the blood stays at one site, the greater the chance white blood cells will build up and cause thickening of the ," Suess said. That narrowing then increases the shear stress on the vessel wall.

Sanford Health biomedical engineer Tyler Remund, who is part of Kelly's product development team, explained the arteries that feed the kidneys are very prone to clotting. Remund earned his bachelor's in from SDSU and then completed his doctorate in biomedical engineering at the University of South Dakota.

"The challenge that has faced the industry is keeping the renal vessels open," he added, noting that the short length and small diameter of renal arteries leave them prone to narrowing once stented.

Opening up opportunities

The fluid flow modeling "helped validate that the configuration is delivering more well developed blood flow with the design," according to Kelly.

"The simulation shows flow behavior next to the artery wall is more ordered, predictable and moderate with the design. It splits the upstream and lets it gradually come to the renals," he said. Gent and Suess confirmed this when they ran the computer simulations.

Only a small number of patients—two per 100,000 a year—are diagnosed with thoracoabdominal aneurysms, according to Kelly. However, most of these patients would not survive traditional surgery, which involves an incision from the chest to the groin. "This less invasive approach could give more patients an option," Kelly pointed out.

This project could lead to more opportunities for the researchers. Gent accompanied the Sanford surgeon to a conference where Kelly presented the work they had done.

"We have a lot of options moving forward," Suess said. "We can do this type of modeling for any stent."

Explore further: Computational fluid dynamics in coronary plaques predict coronary artery disease

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