Many with nonceliac wheat sensitivity have autoimmune diseases

Many with nonceliac wheat sensitivity have autoimmune dz

(HealthDay)—More patients with nonceliac wheat sensitivity (NCWS) and celiac disease (CD) than irritable bowel syndrome (IBS) develop autoimmune diseases (ADs), according to a study published in the September issue of Gastroenterology.

Antonio Carroccio, M.D., from the University of Palermo in Italy, and colleagues conducted a retrospective study of 131 with NCWS and 151 control patients with CD and IBS to examine the prevalence of AD and antinuclear antibodies (ANA). A prospective study was conducted involving 42 patients with NCWS and 100 age- and sex-matched controls with CD or IBS.

The researchers found that 29 percent of patients with NCWS and CD developed ADs (mainly Hashimoto's thyroiditis) compared to 4 percent of patients with IBS (P < 0.001). In the prospective study, 24, 20, and 2 percent, respectively, developed ADs (P < 0.001). Serum samples tested positive for ANA in 46, 24, and 2 percent of samples with NCWS, CD, and IBS, respectively (P < 0.001 for CD and IBS versus NCWS), in the . The corresponding values in the prospective study were 28, 7.5, and 6 percent (P = 0.02 for CD and P = 0.005 for IBS versus NCWS).

"Higher proportions of patients with NCWS or CD develop autoimmune disorders, are ANA positive, and showed DQ2/DQ8 haplotypes compared with patients with IBS," the authors write.

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Journal information: Gastroenterology

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Citation: Many with nonceliac wheat sensitivity have autoimmune diseases (2015, August 27) retrieved 13 April 2024 from
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