Prophylactic azithromycin benefit lasts after lung transplant

Prophylactic azithromycin benefit lasts after lung transplant
(HealthDay)—For patients undergoing lung transplantation (LTx), prophylactic azithromycin is associated with reduced risk of chronic lung allograft dysfunction (CLAD), according to a study published online Aug. 4 in the American Journal of Transplantation.

Noting that prophylactic azithromycin has been shown to improve freedom from bronchiolitis obliterans syndrome two years after LTx, David Ruttens, from KU Leuven and UZ Leuven in Belgium, and colleagues re-evaluated the long-term effects of this approach. They conducted a retrospective, intention-to-treat analysis of a comparing with placebo (43 patients) versus azithromycin (40 patients) after LTx. Seven years after the inclusion of the last subject, they examined CLAD, graft loss (re-transplantation, mortality), evolution of pulmonary function, and functional exercise capacity.

The researchers found that 51 percent of the and 28 percent of the azithromycin group ever developed CLAD after LTx (P = 0.043). The azithromycin group had longer CLAD-free survival (P = 0.024). The proportion of patients with obstructive versus restrictive CLAD was similar between the groups. The groups had similar graft loss: 53 percent in the placebo group versus 40 percent in the azithromycin group (P = 0.27). The azithromycin group had better long-term and functional exercise capacity (P < 0.05).

"In summary, our long-term follow-up data support a sustained benefit of post-transplant, prophylactic azithromycin in prolonging CLAD-free survival and preserving allograft function and exercise capacity," the authors write.


Explore further

Azithromycin may provide benefit for treatment of respiratory disorder

More information: Abstract
Full Text (subscription or payment may be required)

Copyright © 2015 HealthDay. All rights reserved.

Citation: Prophylactic azithromycin benefit lasts after lung transplant (2015, August 13) retrieved 26 May 2019 from https://medicalxpress.com/news/2015-08-prophylactic-azithromycin-benefit-lung-transplant.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
10 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more