Taking antidepressants with cancer drug does not increase breast-cancer recurrence

A large study of patients with breast cancer who took the anti-cancer drug tamoxifen while taking an antidepressant were not found to have an increased risk of recurrence. The Kaiser Permanente study was published today in The Journal of the National Cancer Institute.

Tamoxifen is a commonly prescribed generic drug taken by women with to reduce their chances of developing a recurrence. Tamoxifen is recommended for five years, but has notable side effects including , night sweats and depression. Since is not recommended to alleviate these symptoms in breast-cancer survivors, antidepressants have been increasingly prescribed for relief. Almost half of the 2.4 million breast-cancer survivors in the U.S. take antidepressants.

Previous studies have suggested that antidepressants reduce tamoxifen's effectiveness in lowering subsequent breast-cancer risk.

"Given that thousands of breast-cancer survivors struggle with depression, sleep disturbance, and other side effects while on tamoxifen, our study should help alleviate any concerns physicians have about prescribing antidepressants to their breast-cancer patients to help improve their quality of life," said Reina Haque, PhD, MPH, research scientist, Kaiser Permanente Southern California, Department of Research & Evaluation.

The study population consisted of 16,887 early-stage breast-cancer survivors treated with tamoxifen, as identified through electronic health records of Kaiser Permanente members in California. Nearly half - or 8,089 patients - were prescribed antidepressants.

The patients were followed for a maximum of 14 years and took tamoxifen an average of three years. (The median was 2.7 years.) Researchers found that 2,946 women (17.4 percent) subsequently developed breast cancer over the 14-year follow-up period. The majority of those women (2,512 or 14.9 percent) experienced breast-cancer recurrences in the same breast, while the remainder (434 or 2.5 percent) had cancer in the opposite breast, and the risk of recurrence was similar in women who took antidepressants as among those who did not use .

"We found no increased risk of recurrence, and this finding holds up regardless of the type of antidepressant used. This includes paroxetine, which had previously been reported to interfere with tamoxifen," Dr. Haque added.

Provided by Kaiser Permanente
Citation: Taking antidepressants with cancer drug does not increase breast-cancer recurrence (2015, December 1) retrieved 30 September 2023 from https://medicalxpress.com/news/2015-12-antidepressants-cancer-drug-breast-cancer-recurrence.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

No need to stop antidepressants before plastic surgery, evidence suggests


Feedback to editors