Increased diabetes risk associated with youth antipsychotic treatment, rare with small absolute incidence rates

A review of medical literature suggests antipsychotic treatment in youth was associated with an increased risk of type 2 diabetes, although the condition appeared to be rare with small absolute incidence rates, according to an article published online by JAMA Psychiatry.

The meta-analysis led by Christoph U. Correll, M.D., of the Hofstra Northwell School of Medicine, Hempstead, N.Y., included 13 studies with 185,105 youth exposed to antipsychotics (average age 14.1 years and 59.5 percent male).

The cumulative risk of type 2 diabetes and its incidence rate per patient year of antipsychotic exposure were 2.6 times and three times higher compared with healthy controls and 2.1 times and 1.8 times higher compared with psychiatric patients not exposed to antipsychotics.

The study notes the smaller difference compared with psychiatrically ill patients than to healthy controls reflects that unhealthy lifestyle behaviors and other pharmacological treatments associated with psychiatric disorders likely also contribute to the risk of weight gain or obesity, and type 2 diabetes.


Explore further

Risk of diabetes in children and adolescents exposed to antipsychotics

More information: JAMA Psychiatry. Published online January 20, 2016. DOI: 10.1001/jamapsychiatry.2015.2923
Journal information: JAMA Psychiatry

Citation: Increased diabetes risk associated with youth antipsychotic treatment, rare with small absolute incidence rates (2016, January 20) retrieved 12 December 2019 from https://medicalxpress.com/news/2016-01-diabetes-youth-antipsychotic-treatment-rare.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
2 shares

Feedback to editors

User comments