Low vitamin D linked to dry eye syndromes
Pelin Yildirim, M.D., from the Kocaeli Derince Training and Research Hospital in Turkey, and colleagues evaluated 50 premenopausal women with vitamin D deficiency (serum vitamin D levels <20 ng/mL) and 48 controls for dry eye parameters.
The researchers found that among patients with vitamin D deficiencies, lower scores in Schirmer's test and tear break-up time test (TBUT) and higher in ocular surface disease index were seen compared with controls (P < 0.05). Stanford Health Assessment Questionnaire scores showed no significant correlation with dry eye parameters (P > 0.05). Vitamin D level was negatively correlated with ocular surface disease index (P < 0.001) and positively with Schirmer's test (P = 0.001) and TBUT scores (P = 0.029).
"Dry eye and impaired tear function in patients with vitamin D deficiency may indicate a protective role of vitamin D in the development of dry eye, probably by enhancing tear film parameters and reducing ocular surface inflammation," the authors write.
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