Curcumin may help overcome drug-resistant tuberculosis

New research indicates that curcumin—a substance in turmeric that is best known as one of the main components of curry powder—may help fight drug-resistant tuberculosis. In Asia, turmeric is used to treat many health conditions and it has anti-inflammatory, antioxidant, and perhaps even anticancer properties.

Investigators found that by stimulating called macrophages, curcumin was able to successfully remove Mycobacterium tuberculosis, the causative bacterium of tuberculosis, from experimentally infected cells in culture. The process relied on inhibiting the activation of a cellular molecule called nuclear factor-kappa B.

The ability of curcumin to modulate the immune response to Mycobacterium tuberculosis points to a potential new tuberculosis treatment that would be less prone to the development of drug resistance.

"Our study has provided basic evidence that curcumin protects against Mycobacterium tuberculosis infection in human cells," said Dr. Xiyuan Bai, lead author of the Respirology study. "The protective role of curcumin to fight drug-resistant tuberculosis still needs confirmation, but if validated, curcumin may become a novel treatment to modulate the host immune response to overcome drug-resistant tuberculosis."


Explore further

Cures and curcumin: Turmeric offers potential therapy for oral cancers

More information: Respirology , dx.doi.org/10.1111/resp.12762
Journal information: Respirology

Provided by Wiley
Citation: Curcumin may help overcome drug-resistant tuberculosis (2016, March 24) retrieved 27 June 2019 from https://medicalxpress.com/news/2016-03-curcumin-drug-resistant-tuberculosis.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
7 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more