Distal symmetric polyneuropathy linked to MetS components

Distal symmetric polyneuropathy linked to MetS components

(HealthDay)—Distal symmetric polyneuropathy (DSP) prevalence increases with an increasing number of components of metabolic syndrome, according to a study published online March 10 in Diabetes Care.

Brian C. Callaghan, M.D., from the University of Michigan in Ann Arbor, and colleagues determined the prevalence of symptomatic DSP in the prospective Health, Aging, and Body Composition Study, stratified by glycemic status and the of additional components. DSP was defined as neuropathic symptoms plus one or more of three confirmatory tests (heavy monofilament, peroneal conduction velocity, and vibration threshold).

The researchers found that 21.0 percent of the 2,382 participants with neuropathy measures had diabetes, 29.9 percent had prediabetes, 52.8 percent had metabolic syndrome, and 11.1 percent had DSP. Stratified by glycemic status, as the number of components of metabolic syndrome increased there was an increase in DSP prevalence (P = 0.03). The only metabolic syndrome measures significantly associated with DSP were (cross-sectional model: odds ratio, 1.65) and baseline hemoglobin A1c (longitudinal model: odds ratio, 1.42). Significant associations with multiple secondary neuropathy outcomes were seen for waist circumference and high-density lipoprotein.

"Independent of glycemic , symptomatic DSP is more common in those with additional metabolic syndrome components," the authors write. "However, the issue of which metabolic syndrome components drive this association, in addition to hyperglycemia, remains unclear."

One author disclosed financial ties to the medical device industry.

Explore further

Metabolic syndrome up with ADT in prostate cancer

More information: Abstract
Full Text (subscription or payment may be required)
Journal information: Diabetes Care

Copyright © 2016 HealthDay. All rights reserved.

Citation: Distal symmetric polyneuropathy linked to MetS components (2016, March 16) retrieved 20 October 2019 from https://medicalxpress.com/news/2016-03-distal-symmetric-polyneuropathy-linked-mets.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more