Towards the goal of precision therapy in hepatocellular carcinoma

Towards the goal of precision therapy in hepatocellular carcinoma
Hepatocellular carcinoma is a highly lethal disease, therefore effective and tolerable treatment is urgently needed. Credit: Dr. Nelson S Yee, Bentham Science Publishers

Advances in understanding the molecular genetics of hepatocellular neoplasia have been made, and developing targeted therapeutics in combination with molecular tumor profiling may help accomplish the goal of precision treatment of patients with hepatocellular carcinoma (HCC).

In a recently published article, Dr. Nelson Yee and Dr. Eric Marks provide an updated review of the genetic abnormalities and mechanisms that drive carcinogenesis of HCC, and discuss the targeted therapeutics clinically investigated in with this disease.

The multi-steps formation of HCC typically begins with chronic inflammation of hepatocytes that progressively transform into invasive carcinoma. These events are associated with molecular abnormalities and chromosomal alterations. Aberrant expression or activity of growth factors and receptors, and the associated signaling pathways are implicated in the development and progression of HCC, and they have been exploited as targets for therapy. Among these targeted agents, the multi-kinase inhibitor sorafenib has become the standard for advanced HCC, though its therapeutic benefit is limited.

Targeted agents that inhibit and their downstream signal mediators, angiogenesis, and immunomodulators have been developed and clinically investigated. Continued research will need to focus on utilizing molecular profiles to guide selection of targeted therapy in HCC, with the hope of advancing towards the goal of precision treatment for patients with this malignant disease.

HCC is a highly lethal malignancy, and treatment with improved response and tolerable toxicities is urgently needed. This article provides a current and comprehensive review of the and targeted therapeutics in HCC. Medical researchers, clinical investigators, clinicians, and patients with will be interested in reading the article and find the article informative. Any inquiry or comment, please contact Dr. Nelson Yee.

More information: Eric I. Marks et al. Molecular Genetics and Targeted Therapy in Hepatocellular Carcinoma, Current Cancer Drug Targets (2015). DOI: 10.2174/1568009615666150916092903

Provided by Bentham Science Publishers
Citation: Towards the goal of precision therapy in hepatocellular carcinoma (2016, March 7) retrieved 20 May 2024 from
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