LDL reduction in hypertriglyceridemia varies per statin

LDL reduction in hypertriglyceridemia varies per statin
(HealthDay)—For patients with hypertriglyceridemia, low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) reductions depend of the choice and dose of statin, according to research published in the May 1 issue of The American Journal of Cardiology.

Björn W. Karlson, M.D., Ph.D., from AstraZeneca and the University of Gothenburg in Sweden, and colleagues used data from the individual patient meta-analysis of in at-risk groups: effects of rosuvastatin, atorvastatin, and simvastatin meta-analysis to examine LDL-C and TG reductions in with baseline TG ≥177 mg/dL. Using 15,800 patient exposures to rosuvastatin, atorvastatin, and simvastatin, the least squares mean percentage change from baseline in LDL-C and TG were compared.

The researchers found that the mean reductions in LDL-C varied from −26.9 to −55.5 percent. Significantly greater reductions in LDL-C were seen for 10 to 40 mg rosuvastatin versus equal or double doses of atorvastatin and simvastatin (P < 0.05). The mean reductions in TG varied from −15.1 to −31.3 percent. Significantly greater reductions were seen for rosuvastatin 10 mg versus atorvastatin 10 mg (P < 0.05); similar reductions were seen for 20 to 40 mg rosuvastatin versus equal doses of . Significantly greater reductions were seen for rosuvastatin 20 to 40 mg versus equal or double doses of simvastatin (P < 0.05).

"In patients with hypertriglyceridemia, LDL-C reduction was substantial and dependent on the choice and dose of statin," the authors write.

Several authors disclosed financial ties to AstraZeneca, which funded the study.


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Journal information: American Journal of Cardiology

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