Niacin-ER may be overlooked cause of thrombocytopenia

April 10, 2016

(HealthDay)—Extended-release (ER) niacin is associated with progressive and reversible thrombocytopenia, according to a letter to the editor published online March 25 in the American Journal of Hematology.

Casey O' Connell, M.D., from the Keck School of Medicine of the University of Southern California in Los Angeles, and colleagues describe four (average age, 68.8 years) who were on niacin-ER for 20 months to nine years. All four patients developed progressive thrombocytopenia.

The researchers found that platelets recovered quickly after cessation of niacin-ER, with improvement noted within a month of cessation in all four patients. Based on criteria to determine the level of evidence for a causal association, three patients were found to have a "probable" association and one a "definite" association. The patients were on niacin-ER daily for 59 months, on average, at a median dose of 2,250 mg. Platelets recovered by an average of 91.5 × 109/L, with a mean time to response of 136 days. In two of the four patients who were anemic as well as thrombocytopenic, there was a marked improvement in hemoglobin upon discontinuation of niacin-ER.

"In conclusion, Niacin-ER is known to cause reversible thrombocytopenia, but this effect may be insidious and severe and can be accompanied by reversible anemia, both of which may be easily overlooked in with multiple medical conditions and concomitant medications," the authors write.

Explore further: ACC: Niacin/Laropiprant no benefit in vascular disease

More information: Full Text (subscription or payment may be required)

Related Stories

ACC: Niacin/Laropiprant no benefit in vascular disease

March 12, 2013
(HealthDay)—For patients with preexisting occlusive vascular disease, the combination of niacin and the anti-flushing agent laropiprant provides no benefit and is associated with an increase in serious side effects, according ...

SCCM: circulating histones for most with thrombocytopenia

February 23, 2016
(HealthDay)—Most patients with thrombocytopenia have circulating histones, according to a research letter published online Feb. 22 in the Journal of the American Medical Association to coincide with the Society of Critical ...

Extended elevated recurrence rates for ER-positive breast CA

January 28, 2016
(HealthDay)—Breast cancer patients with estrogen receptor (ER)-positive disease have elevated annualized hazards of recurrence during extended follow-up, according to a study published online Jan. 18 in the Journal of Clinical ...

BADGE exposure can elicit contact allergy reactions

November 6, 2014
(HealthDay)—Exposure to aluminum tubes for pharmaceutical use that are internally lacquered with epoxy resins (ER) based on bisphenol A diglycidyl ether (BADGE) can elicit contact allergy reactions, according to a study ...

Extended-Release niacin raises fasting glucose levels

March 28, 2012
(HealthDay) -- The combination of extended-release niacin (N) with ezetimibe plus simvastatin (E/S) to treat hyperlipidemia is associated with increased fasting glucose (FG) levels compared with E/S alone, but these cases ...

Niacin therapy unhelpful, occasionally harmful, study says

March 9, 2013
A combination drug containing niacin failed to lower the risk of heart attacks or strokes and even proved harmful for some with vascular disease, a study released Saturday reported.

Recommended for you

The molecules that energize babies' hearts

June 14, 2018
A metabolic process that provides heart muscle with energy fails to mature in newborns with thickened heart walls, according to a Japan–Canada research team.

Tobacco aside, e-cigarette flavorings may harm blood vessels

June 14, 2018
Flavor additives used in electronic cigarettes and related tobacco products could impair blood vessel function and may be an early indicator of heart damage, according to new laboratory research in Arteriosclerosis, Thrombosis ...

Scientists identify enzyme responsible for vascular damage caused by aircraft noise

June 14, 2018
In a recent study, scientists at Johannes Gutenberg University Mainz (JGU) have identified an enzyme responsible for aircraft-related vascular damage. The researchers were also able to show that nighttime noise has a particularly ...

World-first test could predict risk of heart attack in coronary artery disease patients

June 14, 2018
Researchers have developed a world-first blood test which improves the prediction of the long-term risk of heart attack or death in those with severe coronary artery disease.

Surgical blood transfusions tied to clot risk

June 13, 2018
(HealthDay)—Blood transfusions around the time of surgery may raise your risk for dangerous blood clots, researchers say.

Massive study sheds light on the genetic roots of atrial fibrillation

June 12, 2018
Patients with atrial fibrillation (AF), a condition causing a rapid, irregular heart rate that can increase the risk of stroke, could use some new treatment options. Despite how common the condition is, the current treatment ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.