From frozen ovaries to lab-grown babies: the future of childbirth

From frozen ovaries to lab-grown babies: the future of childbirth
No more morning sickness for mums to be? Credit: Sebastian Kaulitzki

It is almost 40 years since the first IVF baby, Louise Brown, was born. While this amazing breakthrough was highly controversial at the time, IVF is today commonplace. So how is conception and childbirth likely to change over the next 40 years and beyond?

The rapid pace of research in the areas of fertility and reproduction raises some mind-boggling questions about the future. Will we conceive and grow entirely in laboratories – making sex and pregnancy a thing of the past? And will all future babies be "genetically designed"?

One of the real game changers will be women's ability to preserve their fertility and have children later in life. The procedure of freezing eggs was once fairly unsuccessful. But these days 80-90% of the eggs survive and women have a 97% chance of having a baby if they freeze 40 or more eggs before they turn 35. Another option is for women to freeze ovarian tissue at a young age, which can be thawed and put it back in the body several years later. This is still being researched but babies have been born using this method, and it is only going to get better with time.

Scientists have also successfully created sperm from stem cells and there is no reason why the same cannot be done for . So in 40 years, women will most likely have several viable options to help them preserve their fertility. Hopefully, this will also be socially accepted and an affordable thing to do by then – empowering women to have children when they are ready.

From frozen ovaries to lab-grown babies: the future of childbirth
Eight-day embryo. Credit: ekem, Courtesy: RWJMS IVF Program

But will these changes result in IVF taking over as the main way of reproduction? Despite an enormous amount of research, only a third of women are able to have a baby following IVF today – something that is unlikely to change in the next 40 years. This is partly down to age and the fact that even the healthiest-looking embryo has around a 30% chance of having an abnormal genetic make-up, which can cause miscarriage or genetic defects. Genetic screening before implantation is already used to identify these embryos, but future, improved "non-invasive" testing of the fluid the embryo has grown in will significantly boost IVF rates. Indeed, a century from now IVF is highly likely to be the "normal" way to conceive, making those who conceive naturally look like radical risk takers.

Of course, all this testing may inevitably lead to "designer babies". Indeed, genetic defects will – or rather can – be eliminated in 40 years. We already have the ability to not only look for the most common chromosomal problems, like Down's syndrome, but at each and every gene as well as the areas between the genes. In 40 years tests will be more accurate and the results available immediately, making it possible to identify embryos with disease or a high risk of developing problems later in life. While there are certainly ethical difficulties about this, it is hard to argue against choice if it is informed.

Hopefully by 2056 – and certainly within 100 years – we will also have the ability to correct abnormal genes either in the embryo or foetus using gene editing techniques like CRISPR. The foetal genome can be cut at any desired location and abnormal genes removed or new normal genes added. In this way, babies could be "treated" in the uterus, giving them a chance of a healthy life. The ethics aren't straightforward but it could be argued this is in fact better than current screening programmes designed to identify and exclude rather than save embryos with problems.

From frozen ovaries to lab-grown babies: the future of childbirth
Caesarian sections may replace vaginal birth. Credit: wikimedia, CC BY-SA

Pregnancy and childbirth

In the 1920s, scientist J B S Haldane famously predicted that by 2074 more than 70% of humans would be born from an artificial womb. We are still a long way off that, however babies are coping with spending an increasing amount of gestation time outside the human body. Fertilisation can occur in the lab, as can the first two weeks of the embryo forming. Babies can also survive despite being born at 22-24 weeks – something that was unthinkable in the 1970s.

Even if artificial wombs become possible, it is likely to be highly regulated and restricted to a minority of women who cannot carry a pregnancy or those whose lives would be at significant risk. But as things stand there are already options for these women, such as surrogacy. For that reason, it is unlikely we'll be growing babies in laboratories in the next 40 years. However, as the technology gets tried and tested, couples 100 years from now may well be watching their babies grow in artificial incubators with 24/7 live updates.

Are all women likely to have caesarean sections rather than natural birth in the future? An increasing number of studies are indeed showing that having a planned "elective" caesarean section is the safest way to have a baby – there can never be a guarantee that a labour will go to plan.

But there are risks. Repeated c-sections can cause the placenta in future pregnancies to attach itself so strongly to old scars that it won't come off after delivery. This can lead to significant bleeding and the need for blood transfusion or hysterectomy. Nevertheless, it's a rare condition which is more common in women who have had more than two c-sections. And given that UK families are only having 1.8 babies on average today, the argument for "caesarean delivery for all" will not go away. The fact that many obstetricians choose to give birth in this way shows there is more to it than being "too posh to push". The chances are that attitudes will change in the future and that caesareans will become the norm.

Of course, exactly what will happen by 2056 and beyond is impossible to predict accurately. While history has taught us that things will not stand still, we can be certain that the social and ethical debate is likely to be just as complex as the science.

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This story is published courtesy of The Conversation (under Creative Commons-Attribution/No derivatives).The Conversation

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May 26, 2016
I cant believe that this site says it is for science and then goes on to say that cesarians are safer than natural birth! WOW have you ever talked to a midwife, or looked at any statistics surrounding the overwhelming success of home birth? In all actuality, pregnancy and birth is one process which science has not been able to change with good results. To the contrary, more women suffer from the unnessicary interventions and un needed drugs. Things like apisiotimy, which was never used until men and science started taking over the labor room, this has never been proven by science to help the baby except in extreme circumstances, and obviously does not help the mother, and still it is taught and even considered routine. You need to do your homework and state FACTS not just what hospitals are telling people, with no proof. This is one area that science is not making better, but worse for the vast majority of mothers and babies in the world. CESARIANS ARE NOT SAFER! THAT IS A MYTH!

May 26, 2016
I cant believe that people dont realize that obgyn's are surgeons and not doctors, and therefore are trained to push interventions and surgeries. There is a very good chance that the vast majority of women DO NOT NEED A SURGEON TO GIVE BIRTH! But due to the way of thinking that there is, people dont question what a doctor says to them, you need to QUESTION EVERYTHING that a doctor tells you "needs" to be done, find out why, possible side effects etc. dont just do it because someone in a white coat told you to! THere are choices for mothers these days, you DO NOT have to allow yourself to be bullied and DO NOT have to accept all of the drugs and other interventions that are pushed by doctors today. I reccomend reading some of the work by Ina May Gaskin, she is a world reknown midwife and is helping women reclaim birth from science. Not that I am against there being help available when its needed, but most of the time, the docs just want you to hurry up so they dont miss dinner.

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