Low doses of common cancer drug may promote cancer spread

New research indicates that paclitaxel, which is the most commonly used chemotherapy for breast cancer, suppresses tumors when given at a certain dosage, but at low doses, it actually promotes cancer spread to the liver.

The findings suggest that lowering the dose of to reduce toxic side-effects is not a safe strategy.

"Paclitaxel and its analogous compounds are the first line agents widely used in clinical cancer chemotherapy. However, potential risks and reasonable treatment strategies ofpaclitaxel continue to be widely investigated," wrote the authors of The FEBS Journal study.


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More information: Qi Li et al, Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the mouse model, The FEBS Journal (2016). DOI: 10.1111/febs.13767
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Citation: Low doses of common cancer drug may promote cancer spread (2016, June 22) retrieved 15 August 2020 from https://medicalxpress.com/news/2016-06-doses-common-cancer-drug.html
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