Gut microbiome tied to metabolic hormones in early pregnancy

Gut microbiome tied to metabolic hormones in early pregnancy

(HealthDay)—In overweight and obese women, gut microbiome composition is associated with the metabolic hormonal environment at 16 weeks of gestation, according to a study published in the May issue of Diabetes.

Luisa F. Gomez-Arango, from the University of Queensland in Brisbane, Australia, and colleagues assessed fecal microbiota profiles from 29 overweight and 41 obese pregnant women by 16S rRNA sequencing. Multiplex enzyme-linked immunosorbent assays were used to measure fasting metabolic hormone concentrations.

The researchers found that overweight and had different metabolic hormone levels and microbiome profiles. There were correlations for some metabolic hormone levels with alterations in the relative abundance of specific microbes. There was a strong correlation for adipokine levels with Ruminococcaceae and Lachnospiraceae. A positive correlation was seen for insulin with the genus Collinsella. In addition, gastric inhibitory polypeptide had a positive correlation with the genus Coprococcus and a negative correlation with family Ruminococcaceae.

"This study shows novel relationships between gut microbiome composition and the metabolic hormonal environment in and obese pregnant at 16 weeks gestation," the authors write. "These results suggest that manipulation of the gut microbiome composition may have the potential to influence pregnancy metabolism."

The SPRING study received probiotics and placebo products from Chr. Hansen A/S.

Explore further

Gut microbe may be key to metabolic health and leanness in overweight / obesity

More information: Full Text (subscription or payment may be required)
Journal information: Diabetes

Copyright © 2016 HealthDay. All rights reserved.

Citation: Gut microbiome tied to metabolic hormones in early pregnancy (2016, June 1) retrieved 2 July 2022 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors