Pilocarpine expands schlemm canal in healthy eyes, glaucoma

June 25, 2016

(HealthDay)—Pilocarpine expands the Schlemm canal in eyes with and without glaucoma, according to a study published online June 23 in JAMA Ophthalmology.

Alon Skaat, M.D., from the New York Eye and Ear Infirmary of Mount Sinai in New York City, and colleagues examined the effect of pilocarpine on the structure of the Schlemm canal in vivo in a case-control study. Nine healthy individuals and 10 patients with open-angle glaucoma were prospectively enrolled after a complete ophthalmologic examination. Enhanced depth imaging optical coherence tomographic scans of the Schlemm canal were performed before and after topical pilocarpine administration (1 percent in healthy eyes and 2 percent in eyes with glaucoma).

The researchers found that the mean intraocular pressure decreased from 14.3 to 13.7 mm Hg in healthy eyes and from 17.5 to 16.6 mm Hg in eyes with glaucoma, following pilocarpine administration (P = 0.004 and 0.01, respectively). In healthy eyes and eyes with glaucoma, the mean cross-sectional area of the Schlemm canal increased by 21 and 24 percent, respectively (both P < 0.001). Significant increases were seen in the mean volume of the Schlemm canal in the overlapping area in both healthy eyes and eyes with glaucoma (both P < 0.001).

"These data suggest that pilocarpine expands the Schlemm canal in eyes with and without ," the authors write. "No differences in the effect were identified between the two groups."

Several authors disclosed financial ties to the medical device industry.

Explore further: New glaucoma culprit is found

More information: Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

New glaucoma culprit is found

September 15, 2014
Glaucoma, a leading cause of irreversible blindness, is associated with elevated pressure in the eye. This elevated pressure essentially is due to a plumbing problem. Fluid builds up in the eye, increasing pressure and eventually ...

Disease that causes blindness in children tied to new gene

June 10, 2016
Northwestern Medicine and University of Wisconsin-Madison (UW) scientists have identified a gene that causes severe glaucoma in children. The finding, published in The Journal of Clinical Investigation, validates a similar ...

Distinctive developmental origin for a drainage tube in the eye

July 22, 2014
A Jackson Laboratory based research team has conducted a comprehensive exploration of an eye structure known as Schlemm's canal: a key gatekeeper for the proper flow of eye fluid, presenting a number of insights relevant ...

Venlafaxine-induced rise in intraocular pressure described

May 9, 2016
(HealthDay)—In a case report published online April 30 in Clinical & Experimental Ophthalmology, venlafaxine-induced increase in intraocular pressure (IOP) is described in a patient with open angle glaucoma.

Retinal ganglion cell count IDs normal-tension glaucoma

September 26, 2015
(HealthDay)—Weighted retinal ganglion cell (RGC) count has higher potential than other parameters for differentiating normal eyes from those with glaucoma, according to a study published online Sept. 19 in Clinical & Experimental ...

Agomelatine cuts ocular pressure with glaucoma

April 10, 2015
(HealthDay)—Oral systemic agomelatine has a hypotensive effect that decreases intraocular pressure (IOP) in both eyes of treatment-resistant primary open angle glaucoma (POAG) patients, according to a study published in ...

Recommended for you

Researchers report startling glaucoma protein discovery

October 20, 2017
A discovery in a protein associated with glaucoma was so unheard of that for over two years, researchers ran it through a gauntlet of lab tests and published a new research paper on it. The tests validated what they initially ...

Curve-eye-ture: How to grow artificial corneas

October 19, 2017
Scientists at Newcastle University, UK, and the University of California have developed a new method to grow curved human corneas improving the quality and transparency - solely by controlling the behaviour of cells in a ...

Clinical study success for novel contact lens device aimed to improve glaucoma treatment

October 19, 2017
A novel contact lens device developed by University of Liverpool engineers to improve the treatment of glaucoma has been found to reliably track pressure changes in the eye and be wearable by people who took part in its first ...

Study indicates proof of concept for using a surrogate liquid biopsy to provide genetic profile of retinoblastoma tumors

October 12, 2017
Retinoblastoma is a tumor of the retina that generally affects children under 5 years of age. If not diagnosed early, retinoblastoma may result in loss of one or both eyes and can be fatal. Unlike most cancers that are diagnosed ...

Farsighted children struggle with attention, study finds

October 10, 2017
Farsighted preschoolers and kindergartners have a harder time paying attention and that could put them at risk of slipping behind in school, a new study suggests.

New drug reduces rate of progression of incurable eye disease

October 4, 2017
An international study including researchers from the Centre for Eye Research Australia (CERA) has found a way to slow the progression of dry age-related macular degeneration (AMD) - one of the most common causes of vision ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.