Baseline ALT, AST frequently assessed with statin initiation

July 18, 2016

(HealthDay)—Most Medicare fee-for-service beneficiaries with dyslipidemia who initiate statins undergo baseline alanine aminotransferase (ALT) and aspartate aminotransferase (AST) testing, according to a study published in the Aug. 1 issue of The American Journal of Cardiology.

Matthew L. Maciejewski, Ph.D., from the Durham Veterans Affairs Medical Center in North Carolina, and colleagues examined disparities in guideline-concordant baseline laboratory testing and abnormal laboratory values in a retrospective cohort of 76,868 Medicare fee-for-service beneficiaries from 10 states. Participants had dyslipidemia and initiated a statin from July 1 to Nov. 30, 2011.

The researchers found that baseline laboratory testing rates were 89.3 and 88.8 percent for ALT and AST, respectively. The likelihood of having ALT and AST testing was increased slightly for older adults if they were dually enrolled in Medicaid (relative risk, 1.01) or had multiple chronic conditions compared with none or one condition (relative risks, 1.03, 1.08, and 1.14 for two to three, four to five, and six or more conditions, respectively). Non-Hispanic blacks were less likely than non-Hispanic whites to receive baseline testing (odds ratio, 0.97). Males were less likely than female beneficiaries to receive testing (odds ratio, 0.99). Abnormal values were rarely observed.

"In conclusion, ALT and AST assessment after statin initiation was commonly done as recommended, and there were negligible disparities in testing rates for beneficiaries," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: ALT levels within normal range linked to cardiovascular events

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