Pomegranate finally reveals its powerful anti-aging secret

July 11, 2016
EPFL researcher and last author Johan Auwerx. Credit: © EPFL / Alain Herzog

Are pomegranates really the superfood we've been led to believe will counteract the aging process? Up to now, scientific proof has been fairly weak. And some controversial marketing tactics have led to skepticism as well. A team of scientists from EPFL and the company Amazentis wanted to explore the issue by taking a closer look at the secrets of this plump pink fruit. They discovered that a molecule in pomegranates, transformed by microbes in the gut, enables muscle cells to protect themselves against one of the major causes of aging. In nematodes and rodents, the effect is nothing short of amazing. Human clinical trials are currently underway, but these initial findings have already been published in the journal Nature Medicine.

As we age, our cells increasingly struggle to recycle their powerhouses. Called mitochondria, these inner compartments are no longer able to carry out their vital function, thus accumulate in the cell. This degradation affects the health of many tissues, including muscles, which gradually weaken over the years. A buildup of dysfunctional mitochondria is also suspected of playing a role in other diseases of aging, such as Parkinson's disease.

One molecule plays David against the Goliath of aging

The scientists identified a molecule that, all by itself, managed to re-establish the cell's ability to recycle the components of the : urolithin A. "It's the only known molecule that can relaunch the mitochondrial clean-up process, otherwise known as mitophagy," says Patrick Aebischer, co-author on the study. "It's a completely natural substance, and its effect is powerful and measurable."

The team started out by testing their hypothesis on the usual suspect: the nematode C. elegans. It's a favorite test subject among aging experts, because after just 8-10 days it's already considered elderly. The lifespan of worms exposed to urolithin A increased by more than 45% compared with the control group.

These initial encouraging results led the team to test the molecule on animals that have more in common with humans. In the rodent studies, like with C. elegans, a significant reduction in the number of mitochondria was observed, indicating that a robust cellular recycling process was taking place. Older mice, around two years of age, showed 42% better endurance while running than equally old mice in the control group.

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Human testing underway

Before heading out to stock up on pomegranates, however, it's worth noting that the fruit doesn't itself contain the miracle molecule, but rather its precursor. That molecule is converted into urolithin A by the microbes that inhabit the intestine. Because of this, the amount of urolithin A produced can vary widely, depending on the species of animal and the flora present in the gut microbiome. Some individuals don't produce any at all. If you're one of the unlucky ones, it's possible that juice won't do you any good.

For those without the right microbes in their guts, however, the scientists are already working on a solution. The study's co-authors founded a start-up company, Amazentis, which has developed a method to deliver finely calibrated doses of urolithin A. The company is currently conducting first clinical trials testing the molecule in humans in European hospitals.

Darwin at your service: parallel evolution makes good dinner partnersAccording to study co-author Johan Auwerx, it would be surprising if urolithin A weren't effective in humans. "Species that are evolutionarily quite distant, such as C elegans and the rat, react to the same substance in the same way. That's a good indication that we're touching here on an essential mechanism in living organisms."

Urolithin A's function is the product of tens of millions of years of parallel evolution between plants, bacteria and animals. According to Chris Rinsch, co-author and CEO of Amazentis, this evolutionary process explains the molecule's effectiveness: "Precursors to urolithin A are found not only in pomegranates, but also in smaller amounts in many nuts and berries. Yet for it to be produced in our intestines, the bacteria must be able to break down what we're eating. When, via digestion, a substance is produced that is of benefit to us, natural selection favors both the bacteria involved and their host. Our objective is to follow strict clinical validations, so that everyone can benefit from the result of these millions of years of evolution."

The EPFL scientists' approach provides a whole new palette of opportunities to fight the muscular degeneration that takes place as we age, and possibly also to counteract other effects of aging. By helping the body to renew itself, urolithin A could well succeed where so many pharmaceutical products, most of which have tried to increase muscle mass, have failed. Auwerx, who has also published a recent discovery about the anti-aging effects of another molecule in the journal Science, emphasizes the game-changing importance of these studies. "The nutritional approach opens up territory that traditional pharma has never explored. It's a true shift in the scientific paradigm."

Explore further: A vitamin that stops the aging process of organs

More information: Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents, Nature Medicine, DOI: 10.1038/nm.4132

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2.7 / 5 (12) Jul 11, 2016
I'd like a tub of that-there Pomegranate stuff and some of the right flora, please.

Can they be put together in some concoction?
3.4 / 5 (5) Jul 11, 2016
I fear we have been here many hundreds of times before: hundreds of times before some so called 'super-food' or some other substance, such as anti-oxidants or vitamin etc, promises to reduce aging and initially with what appears to be reasonable evidence but then further later research shows it just doesn't work on humans either because the earlier research on animals was flawed or because the results don't transfer from animal models to human models. We have seen this with, for example, for anti-oxidants and vitamins both of which are now scientifically proven not only to do nothing to slow down aging but to actually SHORTEN human life.
So we must treat this report with skepticism or at the very least reserve all judgment on the claims until if or when we have direct concrete PROOF it does work exactly as desired on humans and with no unacceptable side effects.

2.8 / 5 (11) Jul 11, 2016
Gkam, have you considered using the pomegranate as a suppository?
That might be right up your uh, ally.
2.6 / 5 (5) Jul 11, 2016
Sounds painful.
2.3 / 5 (12) Jul 11, 2016
Estevan, Your fascination with my rectum is disgusting.

And your nose is cold.
3.9 / 5 (7) Jul 11, 2016
Pitiful how this comment section has turned into disgusting comments and personal attacks so much recently.

Can we all please behave like adults?

1 / 5 (3) Jul 11, 2016
Whydening Gyre
4.2 / 5 (5) Jul 11, 2016
I'd like a tub of that-there Pomegranate stuff and some of the right flora, please.

Can they be put together in some concoction?

Some rum in there might be nice. If not - vodka...
3.4 / 5 (5) Jul 12, 2016
humy, not only are you wrong and misinformed, but you also don't belong on this website. As an example of your ineptness, see https://www.ncbi....25078376 . You should be ashamed.

The human system is a much more tightly controlled cybernetic system than that of a rat or a worm, and this is why it's harder to tweak it. Nevertheless, we must try very hard, and throw at it everything we can. You come in the way of this progress, and that's why, even if you may sometimes be right, you still don't belong here. People like you would have us stay exactly where we are, forgetting that aging doesn't stop for our skepticism. Skepticism in scientific belief and avoidance of action are two different things altogether.

It is well known per https://www.ncbi....26848154 that mitochondria are a target for interventions to reduce the deleterious impact of aging.
1.8 / 5 (5) Jul 12, 2016
Humy has been reading and commenting on the articles for several years and has every right to speak his opinion in these Physorg threads as anyone else. YOU are way out of line, mister.
3 / 5 (2) Jul 12, 2016
Humy has been reading and commenting on the articles for several years and has every right to speak his opinion in these Physorg threads as anyone else.

Not when he spreads misinformation and FUD as he did. Maybe he should stick to commenting on experimental physics.
4 / 5 (4) Jul 12, 2016

richk, per https://www.ncbi....23984796 , the production of urolithins from ellagic acid by human gut microbiota correlated at least with clostridium leptum.

As for the paywalled article, Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents (2016), here is authoritative free PDF: https://documents...2016.pdf
2.3 / 5 (3) Jul 13, 2016
The comment above has been reported to Physorg in case it is a scam and an identity stealer or a virus. Use caution and a strong antivirus app.
3.7 / 5 (3) Jul 13, 2016
Humy has been reading and commenting on the articles for several years and has every right to speak his opinion in these Physorg threads as anyone else.

Not when he spreads misinformation and FUD as he did. Maybe he should stick to commenting on experimental physics.
- SausageDog

There would be no reason for humy to spread misinformation since he is well known in Physorg threads. His opinions are HIS opinions whether you agree with them or not. YOU have given us your opinions also, as have everyone else whether misinformed or not. Physorg allows free speech and good ideas, whether alternative or the usual, as long as Physorg guidelines are observed and followed. Do try to be more tolerant.

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