HIV-infected adults with depression have increased risk for heart attack

August 24, 2016, The JAMA Network Journals

Among more than 26,000 human immunodeficiency virus (HIV)-infected adults, those with major depressive disorder (MDD) were more likely to experience a heart attack than those without MDD, according to a study published online by JAMA Cardiology.

With the advent of highly effective antiretroviral therapy and improved survival, people with HIV-infection are living longer and are now at an increased risk for cardiovascular disease (CVD). There is an urgent need to identify novel risk factors and primary prevention approaches for CVD in HIV. Although depression is prevalent in HIV-infected adults and is associated with future CVD in the general population, its association with CVD events has not been examined in the HIV-infected population.

Matthew S. Freiberg, M.D., M.Sc., of the Vanderbilt University School of Medicine, Nashville, Tenn., and colleagues conducted a study that included 26,144 HIV-infected veterans without CVD at baseline (1998-2003) participating in the U.S. Department of Veterans Affairs Veterans Aging Cohort Study from April 2003 through December 2009. At study entry, 4,853 (19 percent) with were identified.

The average age of those with MDD was 47 years and for those without MDD was 48 years. During 5.8 years of follow-up, 490 acute myocardial infarction (AMI; ) events occurred. After adjustment for demographics, CVD risk factors, and HIV-specific factors, the researchers found that HIV-infected adults with MDD had a 30 percent greater risk for having an AMI than did HIV-infected without MDD. This elevation in AMI risk was slightly lessened to 25 percent after further adjustment for other variables, such as hepatitis C infection, kidney disease, alcohol/cocaine abuse or dependence, and hemoglobin levels.

"Our findings raise the possibility that, similar to the general population, MDD may be independently associated with incident atherosclerotic CVD in the HIV-infected population. Considering the dearth of research in this area, future epidemiologic and mechanistic studies that include women and non-VA populations with HIV are needed," the authors write.

Explore further: HIV infection appears associated with increased heart attack risk

More information: JAMA Cardiology. Published online August 24, 2016; DOI: 10.1001/jamacardio.2016.2716

Related Stories

HIV infection appears associated with increased heart attack risk

March 4, 2013
A study that analyzed data from more than 82,000 veterans suggests that infection with the human immunodeficiency virus (HIV) was associated with an increased risk of acute myocardial infarction (AMI, heart attack) beyond ...

Adverse outcomes up with kidney retransplant in HIV+

June 23, 2016
(HealthDay)—Primary HIV+ kidney transplant recipients who lose their graft and seek retransplantation (re-KT) have an increased risk of death and graft loss, according to a study published online June 15 in the American ...

Very low transmission of HIV within couples receiving both ART and PrEP

August 23, 2016
Providing HIV medication to both members of a couple may substantially reduce the risk of transmission within that couple, according to a study in PLOS Medicine.

HIV infection may be a risk factor for heart failure

April 25, 2011
Patients with HIV infection without a prior history of coronary heart disease may be at a higher risk of developing heart failure, according to a report in the April 25 issue of Archives of Internal Medicine.

HIV does not worsen outcomes of liver transplant in HCC

November 4, 2015
(HealthDay)—HIV infection has no impact on prognosis of liver transplantation (LT) for hepatocellular carcinoma (HCC), according to a study published online Oct. 30 in Hepatology.

CD4/CD8 ratio a predictor of heart disease in HIV-infected patients

July 29, 2016
The ratio of CD4 to CD8 T cells in the blood-a marker of immune system health and associated with mortality risk in the general population-is an independent predictor of coronary heart disease in HIV-infected patients, according ...

Recommended for you

Effective drug delivery to heart with tannic acid

September 18, 2018
Typical methods of drug delivery to the heart require surgical procedures involving incisions in the chest wall and bones. To efficiently treat cardiovascular and related vascular diseases without surgery, a KAIST research ...

Daily low-dose aspirin found to have no effect on healthy life span in older people

September 16, 2018
In a large clinical trial to determine the risks and benefits of daily low-dose aspirin in healthy older adults without previous cardiovascular events, aspirin did not prolong healthy, independent living (life free of dementia ...

Financial incentives for cholesterol control may be cost-effective

September 14, 2018
A program that offered financial incentives to both patients and their physicians to control low-density lipoproteins (LDL) cholesterol could be a cost-effective intervention for patients at high risk of cardiovascular disease ...

Apple's smartwatch has a heart monitor now

September 13, 2018
There will soon be another way to monitor your heart—from your wrist.

3-D virtual simulation gets to the 'heart' of irregular heartbeats

September 12, 2018
In a proof of concept study, scientists at Johns Hopkins report they have successfully performed 3-D personalized virtual simulations of the heart to accurately identify where cardiac specialists should electrically destroy ...

Dairy consumption linked to lower rates of cardiovascular disease and mortality

September 12, 2018
Dairy consumption of around three servings per day is associated with lower rates of cardiovascular disease and mortality, compared to lower levels of consumption, according to a global observational study of over 130,000 ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.