Physician-perceived frailty tied to warfarin discontinuation

Physician-perceived frailty tied to warfarin discontinuation

(HealthDay)—Physician-perceived frailty and low life expectancy are the main reasons for warfarin discontinuation in elderly patients, according to a study published online July 29 in the Journal of Thrombosis and Haemostasis.

Giulia Bertozzo, M.D., from the University of Padua in Italy, and colleagues assessed data from very elderly non-valvular atrial fibrillation (NVAF) to examine the reason for warfarin discontinuation and analyze data on subsequent antithrombotic therapy and subsequent mortality, ischemic, and bleeding events. Patients in the study were at least 80 years old and started warfarin after NVAF diagnosis.

The researchers found that over five years, 148 of 798 patients discontinued warfarin. Thromboembolic and major bleeding events were significantly higher and time in therapeutic range (TTR) was significantly lower in patients who discontinued warfarin despite similar CHA2DS2-VASc score. Vascular disease (hazard ratio [HR], 2.5), being 85 years of age or older (HR, 1.4), TTR <60 percent (HR, 1.8), and bleeding events (HR, 2.3) were independent risk factors for warfarin discontinuation. Physician-perceived frailty or low life expectancy (45.9 percent), bleeding complications (19.6 percent), and sinus rhythm restoration (16.9 percent) were the main reasons for warfarin discontinuation.

"Identification of at high risk of bleeding and poor quality of anticoagulation during warfarin is still an unmet clinical problem," the authors write.

Explore further

Most patients taking warfarin long-term do not maintain stable INR values

More information: Abstract
Full Text (subscription or payment may be required)

Copyright © 2016 HealthDay. All rights reserved.

Citation: Physician-perceived frailty tied to warfarin discontinuation (2016, August 17) retrieved 20 November 2019 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments