New hope in fight against aggressive and often hard to treat brain tumour

September 23, 2016

Researchers from the University of Southampton have discovered a potential way of stopping one of the most aggressive types of brain tumour from spreading, which could lead the way to better patient survival.

Glioblastoma is one of the most common types of malignant brain tumours in adults. They are fast growing and can spread easily. The tumour has threadlike tendrils that extend into other parts of the brain making it difficult to remove it all.

Although there have been great advances made in the treatment of Leukaemia's and other cancers, little is known about how Glioblastomas are formed and how these tumours infiltrate the brain tissue.

Published in Molecular Neurobiology, the study led by Dr Elodie Siney under the supervision of Dr Sandrine Willaime-Morawek, Lecturer in Stem Cells and Brain Repair at the University, analysed how enzymes called ADAMs affect the movement and function of the human tumour cells.

The findings suggest that if you are able to block specific enzymes called ADAM10 and ADAM17 the tumour stops growing and spreading. It also moves the cancer cells away from the place where they were growing which could allow them to be removed through traditional cancer treatments such as radiotherapy, chemotherapy or surgery.

"When confirmed in animal models of , this finding will be of great importance for patients and clinicians," said Sandrine. "Glioblastoma is a devastating disease which is often untreatable. We have found that blocking ADAMs may lead to reduced tumour growth and less recurrence following conventional treatments, improving the chance of complete surgical removal and improving survival rates."

Explore further: Study explains mechanisms behind glioblastoma influence on the immune system

More information: Elodie J. Siney et al. Metalloproteinases ADAM10 and ADAM17 Mediate Migration and Differentiation in Glioblastoma Sphere-Forming Cells, Molecular Neurobiology (2016). DOI: 10.1007/s12035-016-0053-6

Related Stories

3D printing brain tumours to improve treatment

May 25, 2016

Scientists at a Heriot-Watt University plan to 3D print tumour-like constructs to better understand the biology of malignant brain tumours that kill around 5,000 people each year in the UK.

Artificial intelligence reveals mechanism behind brain tumour

September 19, 2016

Researchers at Uppsala University have used computer modelling to study how brain tumours arise. The study, which is published today in the journal EBioMedicine, illustrated how researchers in the future will be able to use ...

Scientists discover how to better map brain tumors

November 3, 2015

Scientists have discovered a protein that helps map the edge of brain tumours more clearly so they show up on magnetic resonance imaging (MRI) scans, according to new research presented at the National Cancer Research Institute ...

Recommended for you

Ancient stress response provides clues to cancer resistance

April 25, 2017

Cancer is often able to craftily outwit the best techniques modern medicine has developed to treat it. In an attempt to understand and combat cancer's vaunted prowess, an unusual collaboration between physicists and a leading ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.