Synthetic 3D-printed material helps bones regrow

September 28, 2016
Cross-section of an adult human femur 3-D printed using an ink developed at Northwestern University. Credit: Adam E. Jakus, Northwestern University

A cheap and easy to make synthetic bone material has been shown to stimulate new bone growth when implanted in the spines of rats and a monkey's skull, researchers said Wednesday.

Human trials using the biomaterial, called Hyper-Elastic Bone (HB), could begin in the next five years, according to the research team from Northwestern University.

"We knew this material had great mechanical properties and it was very easy and rapid to 3D print," said study author Adam Jakus, a researcher at Northwestern University, during a conference call with reporters.

"Its biological effects in the outcomes we observed directly were quite astounding."

The material is "made mostly of a ceramic, which contains mineral found in teeth and bones, and polymer, both of which are used in the clinic," said the study in Science Translational Medicine.

Unlike , which are more costly, more brittle and risk being rejected in the patient's body, the biomaterial could be printed into many shapes and cut, folded, and sutured to fit on demand, according to the report.

"When implanted into experimental animals, HB quickly integrated with the surrounding tissue, regenerating bone to promote spinal fusion in rats," said the study.

A larger piece was printed to fill a hole in a 's skull. It healed after four weeks, with no signs of infection or other side effects, and researchers were able to see evidence of new bone growth.

"This work represents what could be the next breakthrough in orthopedic, cranial facial and pediatric surgery when it comes to repairing and regenerating bone in bone to soft tissue defects," said study author Ramille Shah, assistant professor at Northwestern University.

Researchers hope the material will one day offer personalized implants for a range of bone injuries, including spine, dental, reconstructive, and bone cancer surgeries.

"There's a lot of pediatric patients who are born, especially in Third World countries, with orthopedic or maxillofacial defects," said Shah.

"And we hope that because the Hyper-Elastic Bone is scalable and at a lower cost, that it would be accessible to those types of patients."

Explore further: Team uses 3-D tissue engineering to revolutionize dental disease

More information: A. E. Jakus et al. Hyperelastic "bone": A highly versatile, growth factor-free, osteoregenerative, scalable, and surgically friendly biomaterial, Science Translational Medicine (2016). DOI: 10.1126/scitranslmed.aaf7704 , stm.sciencemag.org/content/8/358/358ra127

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