Serious liver-related condition on the rise in the US

A new analysis reveals that cirrhosis and acute on chronic liver failure (ACLF, a deterioration of liver function in patients with cirrhosis that results in the failure of one or more organs) represent a substantial and increasing health and economic burden in the United States.

The number of hospitalizations for cirrhosis nearly doubled from 371,000 in 2001 to 659,000 in 2011. The prevalence of ACLF among those hospitalizations increased from 1.5 percent to 5 percent. The inpatient costs increased twofold for cirrhosis ($4.8 billion to $9.8 billion) and fivefold for ACLF ($320 million to $1.7 billion).

"This study is the first to illustrate the increase in prevalence and cost of ACLF hospitalizations in the U.S., which highlights important public health concerns", said Dr. Alina Allen, lead author of the Hepatology study. "The increasing number of hospitalizations for multiorgan failure in cirrhosis is partly explained by the increase in infectious complications, a recognized leading cause of decompensation and death in this patient population." Dr. Allen added that the care of hospitalized cirrhotic patients in general, and patients with ACLF in particular, is expensive because it requires highly specialized and resource-intensive care, organ-failure support, or .

"Despite major improvements in liver disease management, the care standards seem to be far from optimal, as evident by growing rates of hospitalizations for complications of ," she said. "The concerning trends observed in this study will not change without systematic and coordinated attempts that target healthcare, from risk-factor modification to early diagnosis and better disease management." Although the mortality rates during ACLF hospitalizations decreased over the decade of study, they remained high at 50 percent.


Explore further

New treatment algorithm can predict benefit of treatment in end-stage liver disease

More information: Hepatology, DOI: 10.1002/hep.28812
Journal information: Hepatology

Provided by Wiley
Citation: Serious liver-related condition on the rise in the US (2016, October 3) retrieved 17 May 2021 from https://medicalxpress.com/news/2016-10-liver-related-condition.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
2 shares

Feedback to editors

User comments