Statins offset insulin-related cancer risk in T2DM
Alexandra Kautzky-Willer, M.D., from the Medical University of Vienna, and colleagues characterized all possible associations between individual T2DM therapies, statin use, and site-specific cancers in the Austrian population using medical claims data for 1,847,051 patients with hospital stays during 2006 to 2007.
The researchers found that the risk of cancers of the colon (males only), liver (males only), pancreas, lung (males only), and brain (males only) were increased up to nine-fold for patients treated with insulin or insulin secretagogues; the risk of prostate cancer was decreased strongly. The risks were generally decreased for patients taking statins, with a greater risk reduction among those not receiving antihyperglycemic therapies. The effects were strongest for use of insulin and pancreatic cancer, sulfonylureas or glitazones and skin cancer, and metformin and prostate cancer, corpus uteri, and non-Hodgkin's lymphoma.
"Overall, our data support the hyperglycemia-cancer hypothesis," the authors write. "Therefore, insulin-sparing and insulin-sensitizing drugs should be the preferred treatment choices."
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