Outcomes similar for rx dosing protocols in ectopic pregnancy

Outcomes similar for rx dosing protocols in ectopic pregnancy

(HealthDay)—For ectopic pregnancy, outcomes are similar with a single- and double-dose methotrexate protocol, according to a study published in the November issue of the American Journal of Obstetrics & Gynecology.

Michelle C. Mergenthal, M.D., from the University of Pennsylvania in Philadelphia, and colleagues conducted a multicenter cohort study involving clinical data from women who received medical management for . The authors assessed the rates of human chorionic gonadotropin change and successful pregnancy resolution.

Of the 162 ectopic pregnancies included in the final analysis, 70 percent were treated with single-dose methotrexate and 30 percent with the two-dose protocol. The researchers found that site, race, ethnicity, and reported pain level correlated with differential protocol allocation. Initial human chorionic gonadotropin levels were similar in either protocol, but from day zero to day seven the mean rate of decline of human chorionic gonadotropin was significantly more rapid with the single-dose versus the two-dose protocol (mean change −31.3 percent versus −10.4 percent; P = 0.037). There were no significant differences in success rate or time to resolution for the two protocols.

"In a racially and geographically diverse group of women, the single- and double-dose methotrexate protocols had comparable outcomes," the authors write. "The more rapid human chorionic gonadotropin initial decline in the single-dose group suggested these patients were probably at lower risk for ectopic rupture than those getting the two-dose protocol."


Explore further

Study examines methods, procedures for improved diagnosis of ectopic pregnancy

More information: Full Text (subscription or payment may be required)

Copyright © 2016 HealthDay. All rights reserved.

Citation: Outcomes similar for rx dosing protocols in ectopic pregnancy (2016, November 2) retrieved 25 November 2020 from https://medicalxpress.com/news/2016-11-outcomes-similar-rx-dosing-protocols.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors

User comments