Case report: Ustekinumab for Crohn's continued in pregnancy

December 28, 2016

(HealthDay)—Good outcome has been reported in a pregnant woman who continued ustekinumab (UST) therapy for Crohn's disease during pregnancy, according to a case report published online Dec. 22 in the Journal of Clinical Pharmacy and Therapeutics.

Xavier Cortes, M.D., from the Hospital de Sagunto in Spain, and colleagues describe the case of a with Crohn's disease who was successfully treated with UST maintenance therapy during pregnancy. The 37-year-old patient had been receiving UST for eight months before becoming pregnant. She continued UST treatment after discussion with the obstetric team.

The authors note that the patient had an uneventful pregnancy and delivered a healthy baby boy at term. The patient was in clinical and biological remission during pregnancy and was still in clinical, biological, and endoscopic remission six months after delivery. No side effects were reported during UST therapy, with no recurrent episodes and no reports of problems for the baby at one-year follow-up.

"To our knowledge, this is the first reported use of continued UST therapy for Crohn's disease throughout a pregnancy," the authors write. "The result of treatment was an uncomplicated pregnancy with the mother giving birth to a healthy boy at term and the maintenance of clinical biological and endoscopic remission of Crohn's disease during and after pregnancy."

Explore further: Smoking while pregnant may compromise children's kidney function

More information: Full Text (subscription or payment may be required)

Related Stories

Smoking while pregnant may compromise children's kidney function

December 22, 2016
In a new study, young children showed signs of kidney damage if their mothers smoked while pregnant. The findings, which appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN), add ...

Simultaneous pregnancy and leukaemia offer a treatment challenge

November 13, 2015
The latest case report published in ecancermedicalscience describes the case of a woman who had the double burdens of chronic leukaemia and an unplanned pregnancy - and her happy outcome.

Study finds arthritis drug significantly effective in treating Crohn's disease

November 17, 2016
Researchers at University of California San Diego School of Medicine have shown that ustekinumab, a human antibody used to treat arthritis, significantly induces response and remission in patients with moderate to severe ...

Gaps in knowledge of pharmacokinetic changes in pregnancy and their clinical consequences

November 1, 2016
There is a substantial gap in knowledge of pharmacokinetic changes in pregnancy and their clinical consequences, according to a study published by Shinya Ito and colleagues from the Hospital for Sick Children, Toronto, Canada, ...

New research discoveries on endoscopy during pregnancy

October 31, 2016
According to earlier recommendations, women ought to avoid endoscopy during pregnancy. New analyzes by researchers from the Karolinska Institute and Columbia University could question these recommendations.

Stem cell transplantation does not provide significant improvement for Crohn's disease

December 15, 2015
Among adults with difficult to treat Crohn disease not amenable to surgery, hematopoietic stem cell transplantation, compared with conventional therapy, did not result in significant improvement in sustained disease remission ...

Recommended for you

Sleep quality improves with help of incontinence drug

January 12, 2018
A drug used to curtail episodes of urinary incontinence in women also improves quality of sleep, a researcher at the Stanford University School of Medicine reports.

Frozen embryos result in just as many live births in IVF

January 10, 2018
Freezing and subsequent transfer of embryos gives infertile couples just as much of a chance of having a child as using fresh embryos for in vitro fertilization (IVF), research from Ho Chi Minh City, Vietnam, and Adelaide, ...

Study suggests air pollution breathed in the months before and after conception increases chance of birth defects

January 8, 2018
A team of researchers with the University of Cincinnati and Cincinnati Children's Hospital has found evidence that indicates that pre-and post-pregnant women living in an area with air pollution are at an increased risk of ...

Taking paracetamol during pregnancy may reduce fertility of daughters

January 5, 2018
Taking paracetamol during pregnancy may impair the future fertility of female offspring, according to a review published in Endocrine Connections. The article reviews three separate rodent studies that all report altered ...

Advanced MRI can detect placental perfusion abnormalities in pregnancies complicated by fetal CHD

January 5, 2018
In pregnancies complicated by fetal congenital heart disease (CHD), global placental perfusion was significantly decreased and regional variation of placental perfusion significantly increased as pregnancies progressed, findings ...

Recommendations to improve the quality of ultrasound imaging in obstetrics and gynecology

January 4, 2018
While ultrasound imaging is a commonly used diagnostic tool in obstetrics and gynecology, evidence suggests that the quality of ultrasound examination in clinical practice and ultrasound training in obstetrics and gynecology ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.