Weight gain worsens post-discharge prognosis in acute HF

December 29, 2016

(HealthDay)—For patients with acute heart failure (AHF) who experience minimal weight loss or weight gain, increasing body weight is associated with worse post-discharge prognosis, according to research published in the Jan. 1 issue of JACC: Heart Failure.

Andrew P. Ambrosy, M.D., from the Duke University Medical Center in Durham, N.C., and colleagues conducted a post-hoc analysis of the Acute Study of Clinical Effectiveness of Nesiritide and Decompensated Heart Failure trial to examine changes during and after hospitalization for AHF. Data were included for 4,172 patients with complete body weight data.

The researchers found that the median change in body weight was −1.0 and −2.3 kg at 24 hours and by discharge/day 10, respectively. For patients showing weight loss ≤1 kg or weight gain during hospitalization, increasing body weight during hospitalization correlated with an increase per kg in the odds of 30-day mortality or readmission, after risk adjustment (odds ratio, 1.16). Increasing body weight correlated with a higher risk of 180-day mortality among the subset of patients experiencing >1-kg increase in body weight after discharge (hazard ratio, 1.16).

"A substantial number of patients experienced minimal weight loss or frank in the context of an AHF trial, and increasing body weight in this subset of patients was independently associated with a worse post-discharge prognosis," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: Worse prognosis for heart failure patients with low osmolality

More information: Full Text

Related Stories

Maintaining body weight linked to reduced costs in T2DM

August 30, 2016

(HealthDay)—For patients with type 2 diabetes, maintaining body weight is associated with a reduction in medical care costs, while weight gain is associated with variable cost increases depending on the hemoglobin A1C level, ...

Exenatide does not promote weight loss in schizophrenia

October 5, 2016

(HealthDay)—For antipsychotic-treated obese patients with schizophrenia, glucagon-like peptide-1 receptor agonists (GLP-1RAs) do not appear to promote weight loss, according to a study published online Sept. 26 in Diabetes, ...

Low BMI and death after heart attack

April 19, 2016

Low body mass index increases risk mortality after acute myocardial infarction (AMI), even after adjustment for other health factors that affect body weight, according to a study this week in PLOS Medicine. Emily Bucholz, ...

Most people cycle and regain weight

April 3, 2016

Most people lose, gain and maintain their weight inconsistently, and those who lose the most weight are most likely to keep it off and keep losing, new research reports. The study results will be presented Friday, April 1, ...

Lessons learned from 'The Biggest Loser' study

August 1, 2016

Much media attention was given to a recent Obesity study that found that metabolism remained suppressed even when participants in "The Biggest Loser" television series regained much of the weight they lost while dieting. ...

Recommended for you

Tackling childhood obesity using structured play times

March 17, 2017

How important is physical activity in children under 5? It's a question Trish Tucker, a professor in the School of Occupational Therapy, tackles on a daily basis. She's currently involved in a major research project that ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.