Weight gain worsens post-discharge prognosis in acute HF

December 29, 2016

(HealthDay)—For patients with acute heart failure (AHF) who experience minimal weight loss or weight gain, increasing body weight is associated with worse post-discharge prognosis, according to research published in the Jan. 1 issue of JACC: Heart Failure.

Andrew P. Ambrosy, M.D., from the Duke University Medical Center in Durham, N.C., and colleagues conducted a post-hoc analysis of the Acute Study of Clinical Effectiveness of Nesiritide and Decompensated Heart Failure trial to examine changes during and after hospitalization for AHF. Data were included for 4,172 patients with complete body weight data.

The researchers found that the median change in body weight was −1.0 and −2.3 kg at 24 hours and by discharge/day 10, respectively. For patients showing weight loss ≤1 kg or weight gain during hospitalization, increasing body weight during hospitalization correlated with an increase per kg in the odds of 30-day mortality or readmission, after risk adjustment (odds ratio, 1.16). Increasing body weight correlated with a higher risk of 180-day mortality among the subset of patients experiencing >1-kg increase in body weight after discharge (hazard ratio, 1.16).

"A substantial number of patients experienced minimal weight loss or frank in the context of an AHF trial, and increasing body weight in this subset of patients was independently associated with a worse post-discharge prognosis," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: Worse prognosis for heart failure patients with low osmolality

More information: Full Text

Related Stories

Worse prognosis for heart failure patients with low osmolality

March 21, 2016
(HealthDay)—For patients with heart failure and reduced ejection fraction, low osmolality at discharge is associated with worse all-cause mortality and readmission, according to research published in the April 1 issue of ...

Maintaining body weight linked to reduced costs in T2DM

August 30, 2016
(HealthDay)—For patients with type 2 diabetes, maintaining body weight is associated with a reduction in medical care costs, while weight gain is associated with variable cost increases depending on the hemoglobin A1C level, ...

Exenatide does not promote weight loss in schizophrenia

October 5, 2016
(HealthDay)—For antipsychotic-treated obese patients with schizophrenia, glucagon-like peptide-1 receptor agonists (GLP-1RAs) do not appear to promote weight loss, according to a study published online Sept. 26 in Diabetes, ...

Low BMI and death after heart attack

April 19, 2016
Low body mass index increases risk mortality after acute myocardial infarction (AMI), even after adjustment for other health factors that affect body weight, according to a study this week in PLOS Medicine. Emily Bucholz, ...

Most people cycle and regain weight

April 3, 2016
Most people lose, gain and maintain their weight inconsistently, and those who lose the most weight are most likely to keep it off and keep losing, new research reports. The study results will be presented Friday, April 1, ...

Lessons learned from 'The Biggest Loser' study

August 1, 2016
Much media attention was given to a recent Obesity study that found that metabolism remained suppressed even when participants in "The Biggest Loser" television series regained much of the weight they lost while dieting. ...

Recommended for you

Are sugary drink interventions changing people's behaviour?

July 19, 2017
An evaluation of efforts designed to reduce how many sugary drinks we consume shows some success in changing younger people's habits but warns they cannot be the only way to cut consumption.

Young adult obesity: A neglected, yet essential focus to reverse the obesity epidemic

July 18, 2017
The overall burden of the U.S. obesity epidemic continues to require new thinking. Prevention of obesity in young adults, while largely ignored as a target for prevention and study, will be critical to reversing the epidemic, ...

Weight gain from early to middle adulthood may increase risk of major chronic diseases

July 18, 2017
Cumulative weight gain over the course of early and middle adulthood may increase health risks later in life, according to a new study led by researchers from Harvard T.H. Chan School of Public Health. They found that, compared ...

Study finds children carry implicit bias towards peers who are overweight

June 23, 2017
Even children as young as 9 years old can carry a prejudice against their peers who are overweight, according to a new study led by Duke Health researchers. They might not even realize they feel this way.

Mother's obesity boosts risk for major birth defects: study

June 15, 2017
Children of obese women are more likely to be afflicted by major birth defects, including malformations of the heart and genitals, according to a study published on Thursday.

New study finds more than 2 billion people overweight or obese

June 12, 2017
Globally, more than 2 billion children and adults suffer from health problems related to being overweight or obese, and an increasing percentage of people die from these health conditions, according to a new study.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.