Aromatase inhibitor plus growth hormone can optimize height

Aromatase inhibitor + growth hormone can optimize height

(HealthDay)—Use of an aromatase inhibitor in combination with growth hormone seems effective for optimizing height in 11β-hydroxylase-deficient congenital adrenal hyperplasia (CAH), according to a case report published online Jan. 26 in Pediatrics.

Katherine Hawton, M.B.B.S., from the Bristol Royal Hospital for Children in the United Kingdom, and colleagues describe a 6-year-old patient with CAH who had been suboptimally treated and presented with precocious puberty, hypertension, tall stature, advanced bone age, and a predicted final height of 150 cm.

The researchers confirmed a diagnosis of 11β-hydroxylase deficiency in hormonal profiles and genetic analysis. In an attempt to optimize the patient's growth, he was started on and a third-generation aromatase inhibitor, anastrozole, in addition to glucocorticoid replacement. The patient's growth rate improved significantly after initiation of treatment and his advancement slowed. The patient reached a final height of 177.5 cm, which was 11.5 cm above his mid-parental height.

"This patient is only the second reported case of the use of an in combination with growth hormone to optimize height in 11β-hydroxylase-deficient CAH," the authors write. "This novel treatment proved to be highly efficacious, with no adverse effects."

Explore further

Aromatase inhibitors plus growth hormone may help short adolescent boys grow taller

More information: Full Text (subscription or payment may be required)
Journal information: Pediatrics

Copyright © 2017 HealthDay. All rights reserved.

Citation: Aromatase inhibitor plus growth hormone can optimize height (2017, January 27) retrieved 1 August 2021 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments