Biomarker predicts poor prognosis in African-Americans with triple-negative breast cancer

February 21, 2017
Credit: Georgia State University

Having high levels of a certain biomarker is linked to poor prognosis in African-American patients with triple-negative breast cancer, while the same biomarker doesn't influence disease outcomes in white patients, according to a new study.

Racial disparities in disease, particularly , continue to pose a major challenge in healthcare. African-American are more likely to suffer from a more aggressive course of disease and higher mortality compared to other . In particular, African-American with triple-negative breast cancer have a dismal prognosis.

The dire outcome of this group could indicate that high-risk, African-American breast cancer patients are not being identified as such using standard clinical prognostic tools and aren't being prescribed sufficiently aggressive treatment. Therefore, it's critical to find novel biomarkers that could identify differences in tumor biology between racial groups and serve as risk predictors to help alleviate health disparity in disease outcomes.

In this study, a research team led by Georgia State University examined whether a biomarker called nuclear KIFC1, which has been associated with worse outcomes in breast cancer, can predict risk in triple-negative breast cancer, a subtype that disproportionately affects African-American women.

The researchers assessed the nuclear KIFC1 biomarker in tissue samples from 163 African-American patients and 144 white patients who were treated between the years 2003-2008 at Grady Memorial and Emory University hospitals, 2005-2013 at Northside Hospital and 2001-2012 at Baylor Scott & White Medical Center. Race information in medical records was self-declared by patients. The findings are published in the online journal Scientific Reports.

"We looked at the levels of nuclear KIFC1 in their tumors, and interestingly, we found that African-American women had slightly higher levels, but it was only within African-American patients that the levels mattered for their outcome," said Angela Ogden, lead author of the study and a Ph.D. candidate in Dr. Ritu Aneja's laboratory in Georgia State's Biology Department. "African-American women with high nuclear KIFC1 levels tended to do poorly, whereas in white women, it didn't matter if they had high or low levels. It had no effect on their outcomes."

The researchers further investigated why the biomarker only seems to matter in African-American patients by studying triple-negative breast tumor cells from African-American and .

"We found that if we silence the KIFC1 gene, it had a greater impact on the migration of the African-American cells than it did on the white cells," Ogden said. "It may be that for whatever reason, in African-American breast cancer tumors, KIFC1 helps the cells to migrate and spread to other parts of the body. And for reasons that we currently don't know, that's not the case in white tumors. Ultimately, it may even be that African-American patients could potentially be treated with a KIFC1 inhibitor to help prevent metastasis, but that's for future studies."

The study is multi-institutional with tumor samples from breast cancer patients treated at four different hospitals, so the results can likely be generalized. To ensure certain factors didn't confound the results, the researchers adjusted for tumor stage, age at diagnosis, receipt of chemotherapy and the hospital where patients received chemotherapy. They found nuclear KIFC1 had a significant effect on outcomes in African-American patients, even after adjusting for these factors.

Biomarkers of relevance to specific racial groups are starting to be explored more in scientific studies, Ogden said.

"The approach of treating all patients the same, regardless of their racial or ethnic background, may not be the best approach as genetic ancestry matters," she said. "There may be biomarkers and treatments that work better for people of a certain ancestry, race or ethnicity, instead of a one-size-fits-all approach."

Explore further: Breast cancer prognosis of African-American patients may improve with chemotherapy before surgery

More information: Angela Ogden et al, Multi-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer, Scientific Reports (2017). DOI: 10.1038/srep42289

Related Stories

Breast cancer prognosis of African-American patients may improve with chemotherapy before surgery

January 19, 2017
Administering chemotherapy to African-American breast cancer patients prior to surgery could improve their prognosis and survival rates from the disease, according to a new study.

Biomarker linked to aggressive breast cancers, poor outcomes in African-Americans

December 8, 2013
Among African-American women with breast cancer, increased levels of the protein HSET were associated with worse breast cancer outcomes, according to results presented here at the Sixth AACR Conference on the Science of Cancer ...

Genomic differences between breast cancers of African American and white women identified

September 17, 2015
A study from investigators at the Massachusetts General Hospital (MGH) Cancer Center has, for the first time, identified genomic differences between the breast tumors of African American and white women, differences that ...

Triple negative breast cancer in African-American women has distinct difference

April 22, 2015
What makes triple negative breast cancer more lethal in African American women than White women or women of European descent? A new study reveals specific genetic alterations that appears to impact their prognosis and ultimately ...

Triple-negative breast CA risk up for blacks with benign breast Dz

December 29, 2016
(HealthDay)—African-American (AA) identity is associated with increased risk of triple-negative breast cancer (TNBC) among women with a prior diagnosis of benign breast disease (BBD), according to a study published online ...

Researchers identify breast cancer risk factors for younger, black women

October 19, 2016
Black women under the age of 45 are at increased risk for an aggressive form of breast cancer [estrogen receptor (ER) negative] if they experienced a high number of pregnancies, never breast fed, and/or had higher waist-to-hip ...

Recommended for you

Outdoor light at night linked with increased breast cancer risk in women

August 17, 2017
Women who live in areas with higher levels of outdoor light at night may be at higher risk for breast cancer than those living in areas with lower levels, according to a large long-term study from Harvard T.H. Chan School ...

Scientists develop novel immunotherapy technology for prostate cancer

August 17, 2017
A study led by scientists at The Wistar Institute describes a novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA to directly encode protective antibodies against a cancer specific ...

Scientists develop blood test that spots tumor-derived DNA in people with early-stage cancers

August 16, 2017
In a bid to detect cancers early and in a noninvasive way, scientists at the Johns Hopkins Kimmel Cancer Center report they have developed a test that spots tiny amounts of cancer-specific DNA in blood and have used it to ...

Toxic formaldehyde is produced inside our own cells, scientists discover

August 16, 2017
New research has revealed that some of the toxin formaldehyde in our bodies does not come from our environment - it is a by-product of an essential reaction inside our own cells. This could provide new targets for developing ...

Cell cycle-blocking drugs can shrink tumors by enlisting immune system in attack on cancer

August 16, 2017
In the brief time that drugs known as CDK4/6 inhibitors have been approved for the treatment of metastatic breast cancer, doctors have made a startling observation: in certain patients, the drugs—designed to halt cancer ...

Researchers find 'switch' that turns on immune cells' tumor-killing ability

August 16, 2017
Molecular biologists led by Leonid Pobezinsky and his wife and research collaborator Elena Pobezinskaya at the University of Massachusetts Amherst have published results that for the first time show how a microRNA molecule ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.