Endurance training may have a protective effect on the heart

February 7, 2017, The Physiological Society
heart
Human heart. Credit: copyright American Heart Association

Findings published in Experimental Physiology suggest that exercise could be just as important for your heart heath as cholesterol and a healthy diet.

Expression of used to repair damaged DNA increased in response to endurance exercise, even after just a single session, say scientists. The collaboration between the University of Maryland, the University of Texas Southwestern Medical Center, East Carolina University, the Catholic University of Brasilia and Southern Methodist University shows how physiological stressors like exercise can remodel .

These findings are important for understanding how exercise provides a protective effect on the heart. The researchers hope that by understanding this process and basic heart biology, future research may lead to increased life expectancy and drug-free cures for chronic heart problems, including .

The researchers studied the hearts of mice after 30 minutes of running on a treadmill. They looked at how genes were being expressed compared to those in hearts of mice that had not been exercised. The group results are applicable to humans because these genes are regulated in a similar way to those in humans.

Professor Stephen Roth, one of the co-authors, from University of Maryland's Department of Kinesiology, said,

'The genes that are important for genome stability are upregulated in the heart tissue after a single bout of . This may contribute to the protective effects of exercise on cardiovascular health.'

Explore further: Routine checkup should assess fitness, too

More information: Andrew T. Ludlow et al, Acute exercise activates p38 MAPK and increases the expression of telomere protective genes in cardiac muscle, Experimental Physiology (2017). DOI: 10.1113/EP086189

Related Stories

Routine checkup should assess fitness, too

January 4, 2017
(HealthDay)—Most people know they should have their height, weight, blood pressure and cholesterol checked regularly, but an exercise expert says cardiorespiratory fitness should also be part of a routine medical exam.

Resuming exercise soon after heart attack can improve heart recovery

August 4, 2015
Exercise promotes heart health. However, many lifestyle factors cause heart disease, and regular activity may not be enough to prevent heart attacks. A new study in the American Journal of Physiology–Heart and Circulatory ...

When exercise is unhealthy for the heart

November 26, 2015
Endurance exercise accelerates the development of heart problems in individuals with a particular genetic mutation, a new study in American Journal of Physiology—Heart and Circulatory Physiology reports.

Multifaceted genetic impact of training

September 23, 2016
Endurance training changes the activity of thousands of genes and give rise to a multitude of altered DNA-copies, RNA, researchers from Karolinska Institutet report. The study, which also nuances the concept of muscle memory, ...

Regular exercise can lead to heart disease misdiagnosis

August 9, 2016
Scientists have shown that people who exercise for even a few hours each week can enlarge their hearts. This is a normal and beneficial response to exercise, but until now has only been recognised in athletes. The researchers ...

Recommended for you

Cardiovascular disease related to type 2 diabetes can be reduced significantly

August 16, 2018
Properly composed treatment and refraining from cigarette consumption can significantly reduce the risk of cardiovascular disease resulting from type 2 diabetes, according to a study published in the New England Journal of ...

Genomic autopsy can help solve unexplained cardiac death

August 15, 2018
Molecular autopsies can reveal genetic risk factors in young people who unexpectedly die, but proper interpretation of the results can be challenging, according to a recent study published in Circulation.

Neonatal pig hearts can heal from heart attack

August 15, 2018
While pigs still cannot fly, researchers have discovered that the hearts of newborn piglets do have one remarkable ability. They can almost completely heal themselves after experimental heart attacks.

Fifty percent of cardiovascular patients suffer from multiple diseases

August 15, 2018
New research led by The University of Western Australia has revealed that one in two patients admitted to hospital with a cardiovascular disease is suffering from multiple chronic medical conditions which required complex ...

Innovative triple pill significantly lowers blood pressure, study finds

August 14, 2018
A new low dose three in one pill to treat hypertension could transform the way high blood pressure is treated around the world.

Drug repurposing study sheds light on heart disease risk

August 14, 2018
A team led by researchers at Brigham and Women's Hospital has developed a computational technique to reveal the unknown side effects—both good and bad—of hundreds of drugs. That knowledge could help pharmacologists discover ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.