UK grants first license to make babies using DNA from three people

March 16, 2017 by Maria Cheng
A depiction of the double helical structure of DNA. Its four coding units (A, T, C, G) are color-coded in pink, orange, purple and yellow. Credit: NHGRI

Britain's Newcastle University says its scientists have received a license to create babies using DNA from three people to prevent women from passing on potentially fatal genetic diseases to their children—the first time such approval has been granted.

The license was granted Thursday by the country's fertility regulator, according to the university.

In December, British officials approved the "cautious use" of the techniques, which aim to fix problems linked to mitochondria, the energy-producing structures outside a cell's nucleus. Faulty mitochondria can result in conditions including and major organ failure.

"Mitochondria diseases can be devastating for families affected and this is a momentous day for patients," said Doug Turnbull, director of the research at Newcastle University. The university has said it is aiming to treat up to 25 patients a year.

To help women with mitochondria problems from passing them on to their children, scientists remove the nucleus DNA from the egg of a prospective mother and insert it into a from which the donor DNA has been removed. This can happen before or after fertilization. The resulting embryo ends up with nucleus DNA from its parents but mitochondrial DNA from a donor. The DNA from the donor amounts to less than 1 percent of the resulting embryo's genes.

The license granted to Newcastle University relates only to the clinic's capacity to perform the techniques, Britain's fertility regulator said. The clinic must apply for each individual patient to be treated and no patient application has yet been approved.

Last year, U.S.-based doctors announced they had created the world's first baby using such techniques, after traveling to Mexico to perform the procedure, which has not been approved in the United States.

Critics have raised concerns about the treatment, saying it will put people at unnecessary risk of an untested procedure. Some say women with faulty mitochondria should choose simply to use egg donors and that using the new techniques will open the door to genetically modified "designer babies."

Explore further: A look at the UK's proposal to make babies from 3 people

Related Stories

A look at the UK's proposal to make babies from 3 people

February 3, 2015
As British lawmakers vote Tuesday on whether to legalize the creation of babies made from the DNA of three people, here are some questions and answers about the proposed techniques and the controversy surrounding them.

UK proposes rules for embryos made from 3 people

December 17, 2014
(AP)—New rules proposed in Britain would make it the first country to allow embryos to be made from the DNA of three people in order to prevent mothers from passing on potentially fatal genetic diseases to their babies.

Making embryos from three people doesn't look unsafe

June 3, 2014
Britain's fertility regulator says controversial techniques to create embryos from the DNA of three people "do not appear to be unsafe" even though no one has ever received the treatment, according to a new report released ...

UK 1st country to allow creation of embryos from 3 people

February 25, 2015
(AP)—Britain has become the first country in the world to allow the creation of human embryos from the DNA of three people, a technique intended to help mothers avoid passing on genetically degenerative diseases to their ...

UK: Public OK with creating babies from three people

March 20, 2013
Britain's fertility regulator says it has found broad public support for in vitro fertilization techniques that allow babies to be created with DNA from three people for couples at risk of passing on potentially fatal genetic ...

UK may OK creating babies with DNA from 3 people

June 27, 2013
(AP)—Britain may allow a controversial technique to create babies using DNA from three people, a move that would help couples avoid passing on rare genetic diseases, the country's top medical officer says.

Recommended for you

Psychiatric disorders share an underlying genetic basis

June 21, 2018
Psychiatric disorders such as schizophrenia and bipolar disorder often run in families. In a new international collaboration, researchers explored the genetic connections between these and other disorders of the brain at ...

Deep data dive helps predict cerebral palsy

June 21, 2018
When University of Delaware molecular biologist Adam Marsh was studying the DNA of worms living in Antarctica's frigid seas to understand how the organisms managed to survive—and thrive—in the extremely harsh polar environment, ...

Genetic variation in progesterone receptor tied to prematurity risk, study finds

June 21, 2018
Humans have unexpectedly high genetic variation in the receptor for a key pregnancy-maintaining hormone, according to research led by scientists at the Stanford University School of Medicine. The finding may help explain ...

Shared genetics may shape treatment options for certain brain disorders

June 20, 2018
Symptoms of schizophrenia and bipolar disorder, including psychosis, depression and manic behavior, have both shared and distinguishing genetic factors, an international consortium led by researchers from Vanderbilt University ...

Scientists unravel DNA code behind rare neurologic disease

June 20, 2018
Scientists conducting one of the largest full DNA analyses of a rare disease have identified a gene mutation associated with a perplexing brain condition that blinds and paralyzes patients.

Simple sugar delays neurodegeneration caused by enzyme deficiency

June 20, 2018
A new therapeutic approach may one day delay neurodegeneration typical of a disease called mucopolysaccharidoses IIIB (MPS IIIB). Neurodegeneration in this condition results from the abnormal accumulation of essential cellular ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.