Study identifies a distinct type of common gastrointestinal bleeding

April 21, 2017, Medical University of South Carolina

A unique bleeding syndrome associated with cirrhosis and portal hypertension has been identified by researchers at the Medical University of South Carolina (MUSC), Wake Forest University Medical Center, and the University of Texas Southwestern Medical Center in an article published online on April 21, 2017 by the Journal of Investigative Medicine. The syndrome is characterized by typical presentation with acute bleeding (hematemesis, melena, or hematochezia) and also the presence of chronic gastrointestinal (GI) bleeding, documented as iron deficiency anemia. The investigators have coined a term for the syndrome: acute on chronic bleeding.

"This is recognition of a common syndrome of which practicing physicians should be aware," says Principal Investigator Don C. Rockey, M.D., first author on the article, who serves as the chair of the Department of Medicine and professor of gastroenterology at MUSC.

Of the 1,460 patients with GI bleeding involved in the study, 430 (29 percent) were found to have acute on chronic GI bleeding. The bleeding in patients with upper GI bleeding was most often a result of portal hypertensive upper GI tract pathology.

The investigators advise that clinicians confronted with patients who have acute on chronic bleeding should be aware of the association of this presentation with cirrhosis and for appropriate diagnosis and treatment.

Explore further: Study finds tube placement may not be necessary for treating upper GI bleeds

More information: Journal of Investigative Medicine, DOI: 10.1136/jim-2017-000431

Related Stories

Study finds tube placement may not be necessary for treating upper GI bleeds

March 20, 2017
For many of the millions of patients treated annually in hospitals for upper gastrointestinal (GI) bleeding, there is little value in placing a nasogastric (NG) tube in patients to determine the source of that bleeding or ...

Lower risk of gastrointestinal bleeding for apixaban

April 10, 2017
(HealthDay)—For patients receiving direct oral anticoagulant (DOAC) agents for non-valvular atrial fibrillation, apixaban is associated with a lower risk of gastrointestinal (GI) bleeding than rivaroxaban or dabigatran, ...

Major bleeding risk from drugs similar in elderly

April 17, 2017
(HealthDay)—The risk of major bleeding is similar for older patients with atrial fibrillation taking either antiplatelet or anticoagulant drugs, according to a review published online April 10 in the Journal of Thrombosis ...

PPI cuts risk of warfarin-related upper GI bleeding

December 23, 2016
(HealthDay)—For patients beginning warfarin therapy, proton pump inhibitor (PPI) co-therapy is associated with reduced risk of upper gastrointestinal bleeding, according to a study published in the December issue of Gastroenterology.

Hybrid SPECT-CT greatly improves localization of gastrointestinal bleeding

May 8, 2014
Prompt and accurate localization of the site of bleeding is critical for the management of patients with acute GI bleeding. Planar 99mTc-labeled RBC scintigraphy is sensitive for detection of acute gastrointestinal (GI) bleeding ...

Newer anticoagulants linked to gastrointestinal bleeding

July 19, 2013
(HealthDay)—Patients taking the new generation of oral anticoagulants appear to have a higher risk of gastrointestinal bleeding compared with standard care, particularly when treated for venous thrombosis or acute coronary ...

Recommended for you

Deadly Rift Valley fever: New insight, and hope for the future

July 19, 2018
Health control measures alone could be ineffective in the long term fight against the deadly Rift Valley fever which affects both humans and animals, a new study in the journal PNAS reports.

New guidelines to diagnose, manage rare endocrine disorders

July 19, 2018
International guidelines have been published for the first time to help doctors around the globe diagnose and manage patients with a very rare set of endocrine diseases known as pseudohypoparathyroidism and its related disorders, ...

Overuse of antibiotics not what the doctor ordered

July 19, 2018
With increased use of antibiotics worldwide linked to growing antibiotic resistance, a world-first study co-authored by a QUT researcher has highlighted the growing impact of non-prescription supply of antibiotics in community ...

Alcohol-related cirrhosis deaths skyrocket in young adults

July 18, 2018
Deaths from cirrhosis rose in all but one state between 1999-2016, with increases seen most often among young adults, a new study shows.

Hidden blood in feces may signal deadly conditions

July 17, 2018
(HealthDay)—Even if it's not visible to the naked eye, blood in the stool can be serious—a sign of a potentially fatal disease other than colon cancer, new research suggests.

Childhood abuse linked to greater risk of endometriosis, study finds

July 17, 2018
Endometriosis, a painful condition that affects one in 10 reproductive-age women in the U.S., has been linked to childhood physical and sexual abuse, according to findings published today in the journal Human Reproduction.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.