New medication significantly decreases involuntary movement

April 7, 2017, University of South Florida

Antipsychotic treatment can cause involuntary movements such as lip smacking, tongue protrusions and excessive eye blinking. These movements typically occur after more than 3 months of treatment and are called tardive dyskinesia.

Robert A. Hauser, MD, MBA, professor of neurology at the University of South Florida in Tampa, is the lead author of a study published in the American Journal of Psychiatry that concludes valbenazine administered once daily can significantly reduce tardive dyskinesia in patients with schizophrenia, schizoaffective disorder and .

"One approach to managing tardive dyskinesia is to discontinue antipsychotic treatment or reduce the dosage, but these options are not always feasible, because withdrawal can exacerbate tardive dyskinesia symptoms or have a negative impact on psychiatric status. Moreover, tardive symptoms often persist even after discontinuation or dosage reduction," wrote Dr. Hauser, who directs the Parkinson's Disease and Movement Disorders Center at USF.

Valbenazine is a selective vesicular monoamine transporter 2 inhibitor. Two hundred twenty-five people with schizophrenia, schizoaffective disorder or a mood disorder participated in the phase 3 randomized double blind, placebo-controlled trial.

Forty-percent of those who received valbenazine 80mg/day improved by at least 50 percent. That's compared to just 8 percent in the placebo group.

Researchers also determined that valbenazine was well tolerated. Drowsiness, restlessness and dry mouth were reported as adverse effects.

Explore further: Investigational drug may reduce involuntary movements

Related Stories

Investigational drug may reduce involuntary movements

April 12, 2011
Results of the first randomized, placebo-controlled long-term clinical trial show the investigational drug safinamide may reduce dyskinesia or involuntary movements in mid-to-late stage Parkinson's disease. The findings will ...

New therapeutic principle for Parkinsonian dyskinesia shows clinical effect

February 10, 2015
Involuntary dyskinetic movements induced by treatment with levodopa (L-dopa) are a common problem for people with Parkinson's disease. Now, however, researchers at Karolinska Institutet and Lund University in Sweden seem ...

Non-dopaminergic drug preladenant reduces motor fluctuations in patients with Parkinson's disease

February 10, 2011
Preladenant, a non-dopaminergic medication, reduces off time in patients with Parkinson's disease receiving standard dopamine therapy, an international study led by the University of South Florida found.

FDA approves new drug for schizophrenia, bipolar disorder

September 18, 2015
(HealthDay)—A new antipsychotic drug to treat schizophrenia and bipolar disorder in adults has been approved by the U.S. Food and Drug Administration.

New drugs may improve quality of life for people with Parkinson's disease

March 14, 2013
Three studies released today present possible positive news for people with Parkinson's disease. The studies, which will be presented at the American Academy of Neurology's 65th Annual Meeting in San Diego, March 16 to 23, ...

Is left-handedness higher among those suffering from psychosis?

October 30, 2013
Researchers have long studied the connections between hand dominance and different aspects of the human brain. A new study out today in SAGE Open finds that among those with mental illnesses, left-handers are more likely ...

Recommended for you

Social media is affecting the way we view our bodies—and not in a good way

November 15, 2018
Young women who actively engage with social media images of friends who they think are more attractive than themselves report feeling worse about their own appearance afterward, a York University study shows.

Study finds mindfulness apps can improve mental health

November 15, 2018
A University of Otago study has found that using mindfulness meditation applications (apps) on phones is associated with improvements in people's mental health.

New research has revealed we are actually better at remembering names than faces

November 14, 2018
With the Christmas party season fast approaching, there will be plenty of opportunity to re-live the familiar, and excruciatingly-awkward, social situation of not being able to remember an acquaintance's name.

Older adults' abstract reasoning ability predicts depressive symptoms over time

November 14, 2018
Age-related declines in abstract reasoning ability predict increasing depressive symptoms in subsequent years, according to data from a longitudinal study of older adults in Scotland. The research is published in Psychological ...

The illusion of multitasking boosts performance

November 13, 2018
Our ability to do things well suffers when we try to complete several tasks at once, but a series of experiments suggests that merely believing that we're multitasking may boost our performance by making us more engaged in ...

Brain changes found in self-injuring teen girls

November 13, 2018
The brains of teenage girls who engage in serious forms of self-harm, including cutting, show features similar to those seen in adults with borderline personality disorder, a severe and hard-to-treat mental illness, a new ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.