Combined urine test for T2:ERG, PCA3 ups prostate CA detection

May 22, 2017

(HealthDay)—Testing for combined urinary PCA3 and TMPRSS2:ERG (T2:ERG) RNA can improve detection of prostate cancer, according to a study published online May 18 in JAMA Oncology.

Martin G. Sanda, M.D., from the Emory University School of Medicine in Atlanta, and colleagues conducted a multicenter diagnostic evaluation and validation in academic and community-based ambulatory urology clinics. A sample of men presenting for first-time without preexisting prostate cancer were enrolled: 516 in the developmental cohort and 561 in the validation cohort. Urinary PCA3 and T2:ERG RNA were measured before prostate biopsy.

The researchers found that at thresholds that preserved 95 percent sensitivity for detecting aggressive prostate cancer, combining testing of urinary T2:ERG and PCA3 improved specificity from 18 to 39 percent in the developmental cohort. Improvement of specificity was also seen in the validation cohort (from 17 to 33 percent), while for aggressive prostate detection, high sensitivity (93 percent) was preserved. Using the urine assay results to select men for biopsy would have resulted in 42 percent of unnecessary prostate biopsies being averted. In cost analysis, the urinary testing algorithm was found to have greater potential benefit for restricting biopsy in younger men.

"Combined urinary testing for T2:ERG and PCA3 can avert unnecessary while retaining robust sensitivity for detecting aggressive with consequent potential health care cost savings," the authors write.

Several authors disclosed financial ties to pharmaceutical and diagnostic companies, including Hologic, which manufactures the Progensa PCA3 assay and is a licensee of the diagnostic field of use for T2:ERG.

Explore further: PCA3 assay ups predictive accuracy for repeat biopsy

More information: Abstract/Full Text

Related Stories

PCA3 assay ups predictive accuracy for repeat biopsy

June 13, 2013
(HealthDay)—For men with at least one prior negative biopsy, urinary PCA3 scores, together with serum prostate-specific antigen and other clinical information, improve the prediction accuracy for repeat biopsy outcome, ...

Surveillance biopsy timing not tied to reclassification

April 22, 2017
(HealthDay)—Timing of the first active surveillance biopsy is not associated with increased adverse reclassification of prostate cancer, according to a study published in the April issue of The Journal of Urology.

Urine-based test improves on PSA for detecting prostate cancer

May 18, 2015
A new urine-based test improved prostate cancer detection - including detecting more aggressive forms of prostate cancer - compared to traditional models based on prostate serum antigen, or PSA, levels, a new study finds.

Increase in prostate needle biopsy-linked infection in N.Y.

April 18, 2017
(HealthDay)—Infectious complications after prostate needle biopsy increased from 2011 to 2014 across New York State, according to a study published in the April issue of The Journal of Urology.

One in four men with suspected prostate cancer could avoid unnecessary biopsy if given an MRI scan first

January 20, 2017
Giving men with suspected prostate cancer an MRI scan could improve diagnosis and save those who do not have aggressive cancers from having an unnecessary biopsy, according to a study published in The Lancet.

Recommended for you

Scientists block the siren call of two aggressive cancers

January 23, 2018
Aggressive cancers like glioblastoma and metastatic breast cancer have in common a siren call that beckons the bone marrow to send along whatever the tumors need to survive and thrive.

'Hijacker' drives cancer in some patients with high-risk neuroblastoma

January 23, 2018
Researchers have identified mechanisms that drive about 10 percent of high-risk neuroblastoma cases and have used a new approach to show how the cancer genome "hijacks" DNA that regulates other genes. The resulting insights ...

Enzyme inhibitor combined with chemotherapy delays glioblastoma growth

January 23, 2018
In animal experiments, a human-derived glioblastoma significantly regressed when treated with the combination of an experimental enzyme inhibitor and the standard glioblastoma chemotherapy drug, temozolomide.

Study: Cells of three advanced cancers die with drug-like compounds that reverse chemo failure

January 23, 2018
Researchers at Southern Methodist University have discovered three drug-like compounds that successfully reverse chemotherapy failure in three of the most commonly aggressive cancers—ovarian, prostate and breast.

Researchers identify a protein that keeps metastatic breast cancer cells dormant

January 23, 2018
A study headed by ICREA researcher Roger Gomis at the Institute for Research in Biomedicine (IRB Barcelona) has identified the genes involved in the latent asymptomatic state of breast cancer metastases. The work sheds light ...

Boosting cancer therapy with cross-dressed immune cells

January 22, 2018
Researchers at EPFL have created artificial molecules that can help the immune system to recognize and attack cancer tumors. The study is published in Nature Methods.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.