Scientists uncover dietary strategy to address obesity using component in red chili

chili peppers
Credit: CC0 Public Domain

Scientists have discovered a dietary strategy that may address obesity by reducing endotoxemia, a major contributor to chronic, low-grade inflammation (CLGI). The researchers uncovered an interaction between dietary capsaicin (CAP), the major pungent component in red chili, and gut microbiota. This novel mechanism for the anti-obesity effect of CAP acts through prevention of microbial dysbiosis and the subsequent gut barrier dysfunction that can lead to CLGI.

The research is published May 23rd in mBio, an open access journal of the American Society for Microbiology.

Little is known about the role of gut microbiota in the anti-obesity effect of CAP. High throughput 16S rRNA gene sequencing revealed that CAP significantly increased gut health-beneficial butyragenic bacteria and decreased LPS-producing bacteria and LPS biosynthesis. By using antibiotics and microbiota transplantation, the investigators showed that plays a causal role in dietary CAP-induced protective phenotype against high-fat-diet-induced CLGI and obesity.

Moreover, cannaboid receptor type 1 (CB1) inhibition was partially involved in the beneficial effect of CAP. Together, these data suggest that the is a critical factor for the anti-obesity effects of CAP.


Explore further

Changes in gut microbiota after unhealthy diet may protect from metabolic disease

Journal information: mBio

Citation: Scientists uncover dietary strategy to address obesity using component in red chili (2017, May 23) retrieved 23 August 2019 from https://medicalxpress.com/news/2017-05-scientists-uncover-dietary-strategy-obesity.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more