High HCV cure rates in HIV coinfection cases at urban clinic

June 16, 2017

(HealthDay)—For patients in an urban clinic with hepatitis C virus (HCV) with HIV coinfection, HCV treatment is effective with standardized nurse/pharmacist support, according to a study published online June 13 in Hepatology.

Oluwaseun Falade-Nwulia, M.B.B.S., M.P.H., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues examined HCV treatment outcomes among 255 HCV coinfected patients (88 percent black) initiating direct-acting antivirals between February 2014 and March 2016 in an urban clinic. Patients received standardized HIV nurse/pharmacist support, which included telephone calls and nurse visits.

The researchers found that 60 percent of participants had significant fibrosis and 30 percent had received treatment for HCV. Ninety-one percent of patients received ledipasvir/sofosbuvir with or without ribavirin and received 12 weeks of treatment. The sustained virologic response rate was 97 percent, with no variation by race (black and non-black, 96 and 97 percent, respectively), history of drug use, alcohol use, or psychiatric diagnosis.

"HCV treatment was highly effective among HIV-infected patients who received care within an integrated / adherence support program," the authors write. "These results suggest that race and psychosocial comorbidity may not be barriers to HCV elimination."

Explore further: Investigational dose of oral interferon-free treatment can cure hepatitis C in children

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Investigational dose of oral interferon-free treatment can cure hepatitis C in children

April 21, 2017
A study presented today that evaluated an investigational dosage of once-daily ledipasvir 45 mg/sofosbuvir 200 mg (LDV/SOF) in children aged six to 11 years infected with the Hepatitis C virus (HCV), found that 99% of children ...

SVR rates up with new regimens for HCV and HIV coinfection

February 24, 2015
(HealthDay)—For patients with hepatitis C virus (HCV) genotype 1 and HIV coinfection, new regimens are effective and correlate with high rates of sustained virologic response (SVR) after treatment, according to two studies ...

Pharmacist program can improve IFN-beta adherence in MS

May 17, 2017
(HealthDay)—A pharmacist medication adherence program can improve adherence to interferon-beta (IFN-β) among patients with relapsing-remitting multiple sclerosis (RRMS), according to a letter to the editor published online ...

Most patients prefer oral dual therapy in chronic hepatitis C

September 20, 2016
(HealthDay)—For patients with chronic hepatitis C (CHC), most prefer oral therapy with sofosbuvir (SOF) and ribavirin (RBV) versus triple therapy involving pegylated interferon (PegIFN), according to a study published online ...

Patient satisfaction high with nurse-led chronic kidney Dz care

February 8, 2017
(HealthDay)—For patients with chronic kidney disease (CKD), patient satisfaction is high with care at nurse-led clinics, according to a study published online Feb. 3 in the Journal of Renal Care.

Sofosbuvir plus ledipasvir seems effective for HCV genotype 1

November 4, 2014
(HealthDay)—For patients with chronic hepatitis C virus genotype 1 (HCV GT-1) infection who are ineligible for interferon therapy, and who relapsed after sofosbuvir and ribavirin treatment, sofosbuvir plus ledipasvir is ...

Recommended for you

Study reveals new therapeutic target for slowing the spread of flu virus

June 22, 2018
Influenza A (flu A) hijacks host proteins for viral RNA splicing and blocking these interactions caused replication of the virus to slow, according to new research published in Nature Communications by Kristin W. Lynch, Ph.D., ...

First ancient syphilis genomes decoded

June 21, 2018
An international research team, including scientists from the Max Planck Institute for the Science of Human History, the University of Tübingen, the National School of Anthropology and History in Mexico City, and the University ...

Rhesus macaque model offers route to study Zika brain pathology

June 21, 2018
Rhesus macaque monkeys infected in utero with Zika virus develop similar brain pathology to human infants, according to a report by researchers at the California National Primate Research Center and School of Veterinary Medicine ...

California Aedes mosquitoes capable of spreading Zika

June 21, 2018
Over the last five years, Zika virus has emerged as a significant global human health threat following outbreaks in South and Central America. Now, researchers reporting in PLOS Neglected Tropical Diseases have shown that ...

Breakthrough treatment for crippling jaw disease created

June 20, 2018
A first-ever tissue implant to safely treat a common jaw defect, known as temporomandibular joint dysfunction, has been successfully tested by UCI-led researchers in a large animal model, according to new findings.

Cell-free DNA profiling informative way to monitor urinary tract infections

June 20, 2018
Using shotgun DNA sequencing, Cornell University researchers have demonstrated a new method for monitoring urinary tract infections (UTIs) that surpasses traditional methods in providing valuable information about the dynamics ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.