New process may lead to vaccine for schistosomiasis

Cornell and Ludwig Institute for Cancer Research scientists have developed a way to produce a protein antigen that may be useful as vaccine for schistosomiasis – a parasitic disease that infects millions of people, mostly in tropical and subtropical climates – according to new research in the journal Protein Expression and Purification, June 2017.

If clinical trials succeed, this vaccine may lead to a substantial decrease in the global number of schistosomiasis cases, which rank second only to malaria. The vaccine may have the added benefit of potentially reducing the incidence of .

Carl Batt, Cornell's Liberty Hyde Bailey Professor in Food Science, and colleagues Leonardo Damasceno, Ph.D. '08, of the Hertape Animal Health group in Brazil, and Gerd Ritter, of the Ludwig Institute for Cancer Research, established and refined the production of the antigen Sm14, using a microbial host. Sm14 holds promise to stimulate an immune response in humans, serving as a potential preventative vaccine for schistosomiasis.

"There is an association between parasitic infections and the occurrence of subsequent cancers. Schistosomiasis is not only a chronic disease but infected individuals have an enhanced propensity to get bladder ," said Batt. "If you immunize people with an antigen that induces an immune response against schistosomiasis, there will likely be benefits not only in controlling the immediate infection but also a means to avoid bladder cancer."

Schistosomiasis is caused by parasitic worms called Schistosoma mansoni, generally found in fresh water in lakes and rivers around the world, notably Africa and South America. The parasite is not found in the United States, according to the World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention.

Both adults and children are susceptible to the disease. Schoolchildren – when they fish, swim or play in schistosoma-infested water – are particularly vulnerable to infection. WHO estimates that about 240 million people worldwide are infected and more than 66.5 million were treated for the disease in 2015.

"Ideally your immune system should rebuff these parasites, but they have the ability to suppress the human . Thus, the worms avoid being killed by the immune system and they eventually target the human liver," said Batt. "There is a very strong association between bladder cancer and a previous schistosomiasis infection."

If the medical world aims to prevent , then it makes sense to immunize people against the parasite, said Batt.

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More information: Leonardo Damasceno et al. Process development for production and purification of theSchistosoma mansoniSm14 antigen, Protein Expression and Purification (2017). DOI: 10.1016/j.pep.2017.04.002
Provided by Cornell University
Citation: New process may lead to vaccine for schistosomiasis (2017, June 12) retrieved 22 May 2022 from
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