New device could make closing surgical incisions a cinch

July 7, 2017 by Bridget Kuehn, Cornell University

Like many surgeons, Dr. Jason Spector is often faced with the challenge of securely closing the abdominal wall without injuring the intestines. If the process goes awry, there can be serious consequences for patients, including bowel perforations or a hernia at the incision site. Often, repairing these complications requires additional surgeries.

"I've done a lot of incisional hernia repairs on people who've had two, three or more hernia repairs," said Spector, professor of surgery () and of plastic surgery in otolaryngology at Weill Cornell Medicine, an adjunct professor in the Meinig School of Biomedical Engineering and a plastic surgeon at NewYork-Presbyterian/Weill Cornell Medical Center.

Unsatisfied with the existing tools to help prevent these poor outcomes, Spector turned to his long-time collaborator David Putnam, associate professor in the Meinig School. Spector asked for material that would be strong enough to protect the from a needle puncture and bendable enough to insert through a laparotomy incision that would quickly dissolve in the body.

As it turned out, Putnam's then graduate student Nicole Ricapito had created and was testing a material that met those specifications. In a study published May 31 in Acta Biomaterialia, the collaborators and their colleagues demonstrated that the compound was strong enough protect mice intestines during suturing of the abdomen and quickly dissolved in the body.

"It was bendy and stretchy and degraded really fast," Putnam said. "It was a match made in heaven."

The compound is made up of polyethylene glycol, a chemical compound used in laxatives and many , and dihydroxyacetone (DHA), a natural byproduct of the breakdown of glucose in the body. The U.S. Food and Drug Administration has approved the use of DHA in nutritional supplements and spray tanners. The lends flexibility to the and DHA adds strength, Putnam said. Both break down when exposed to water in the body.

In the study, the material was used in lieu of plastic or metal devices called retractors that surgeons typically use to protect the intestines. Traditional retractors must be removed before the incision is completely closed, leaving the surgeon to carefully make the final stiches without protection for the intestines. But Spector and Putnam's device is left behind in the abdominal cavity, allowing the final sutures to be made with protection still in place. The study found that the device dissolved within three hours of the surgery, leaving no scarring or signs of toxicity.

The next step for the collaborators will be to try to replicate the results with further preclinical testing. If further study of the device shows it to be safe and effective, Spector and Putnam hope to pursue commercial development. Cornell University has filed a patent for the device.

If all goes well, Spector said this flexible material might one day help surgeons more confidently and securely close abdominal incisions.

"I hope it will lead to fewer incisional hernias," he said. "In addition, the implantable device could be used in a multitude of situations where surgeons want to protect vital structures from inadvertent needle puncture, but using a removable retractor would prove difficult or impossible."

Explore further: New desktop sterilization device disinfects cell phones in just 10 minutes

More information: Omer E. Kaymakcalan et al. Transient phase behavior of an elastomeric biomaterial applied to abdominal laparotomy closure, Acta Biomaterialia (2017). DOI: 10.1016/j.actbio.2017.05.055

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