Effects of composites containing bioactive glasses on demineralized dentin

July 4, 2017, Asociacion RUVID
A: Demineralized dentin with a number of collagen fibres, that if not preserved and remineralized, these can be degraded by the action of the dentinal proteolytic enzymes. B: Dentin treated with resin with fluoride-containing bioactive glass, which presents mineral precipitations – signs of remineralization.

Bacterial plaque causes tooth decay due to acids produced by different bacteria species; this has trigged an intense research activity for the development of novel restorative biomaterials with protective and self-healing remineralizing properties. In this new study, Salvatore Sauro, a professor of CEU Cardenal Herrera University (Spain) specialized in the development of innovative dental biomaterials, has collaborated with several researchers from Finland, Brazil, Belgium, Germany and the United Kingdom in order to reach this goal. The collaborative generated two new dental restorative biomaterials containing bioactive glasses, and assessed their effectiveness in reducing the enzymatic auto-degradation of collagen fibres and inducing their remineralization.

The aim of the study was to evaluate the inhibition of endogenous proteolytic enzymes of dentin and the induced by two different innovative experimental resins containing bioactive glasses: one containing micro-particles of Bioglass 45S5 and another containing micro-particles of an experimental bioactive glass enriched with fluoride and a high amount of phosphates. Their anti-degradation effects were evaluated on completely demineralized human dentin specimens after immersion in artificial saliva for a period of thirty days by means of an immunohistochemical process. The remineralization was also evaluated by means of infrared spectroscopy and scanning electron microscopy.

Greater effectiveness with fluoride and phosphates

According to Professor Sauro and his co-authors, "The resin-based material containing the experimental bioactive glass enriched with fluoride and phosphates [was] more efficient in inhibiting the enzymatic-mediated degradation of demineralized dentine collagen, and more bioactive than the one containing Bioglass 45S5. This was mainly due to the fluoride ions, as well as to the large amount of phosphates released by the material, which accelerated dentin remineralization and reduced the degradation of demineralized dentin collagen via inhibition of matrix metalloproteinases and cysteine cathepsins.

This type of experimental bioactive material would therefore be more suitable for the development of new restorative dental materials for the clinical treatment of the dental caries.

Professor Sauro spends most of his time in the development of minimally invasive treatments and therapeutic bioactive dental composites for the treatment and restoration of caries-affected dentin, such as the samples tested in this study. He pursues treatments that are able to prevent the degradation of collagen and evoke the remineralization of demineralized dental tissues.

Explore further: A treatment for osteoporosis and bone cancer, employed for the first time in dental filling procedures

More information: A. Tezvergil-Mutluay et al. Effects of Composites Containing Bioactive Glasses on Demineralized Dentin, Journal of Dental Research (2017). DOI: 10.1177/0022034517709464

Related Stories

A treatment for osteoporosis and bone cancer, employed for the first time in dental filling procedures

October 22, 2014
Journal of Dental Research publishes a paper directed by Salvatore Sauro, Professor at University CEU Cardenal Herrera in Spain, in collaboration with international researchers from Finland, Brazil, United States and United ...

Grape seed extract could extend life of resin fillings

May 9, 2017
A natural compound found in grape seed extract could be used to strengthen dentin—the tissue beneath a tooth's enamel—and increase the life of resin fillings, according to new research at the University of Illinois at ...

Chemical composition and microhardness of human enamel treated with fluoridated whintening agents

June 12, 2017
Aesthetic treatments are always widely sought by dental patients, especially dental whitening, in order to get whiter smiles. The big demand for this type of procedure raises the concern in the dental research community that ...

Professor unveils first data on new dental fillings that will repair tooth decay

September 26, 2016
The first data on dental fillings that can actively repair tooth decay is presented by Professor Robert Hill. Professor Hill is Chair of Physical Sciences at the Institute of Dentistry at Queen Mary University of London and ...

Nanotechnology may increase longevity of dental fillings

July 1, 2009
Tooth-colored fillings may be more attractive than silver ones, but the bonds between the white filling and the tooth quickly age and degrade. A Medical College of Georgia researcher hopes a new nanotechnology technique will ...

Postponing restorative intervention of occlusal dentin caries by non-invasive sealing

March 16, 2016
Today at the 45th Annual Meeting & Exhibition of the American Association for Dental Research, researcher Vibeke Qvist, University of Copenhagen, Denmark, will present a study titled "Postponing Restorative Intervention of ...

Recommended for you

Researchers discover cellular messengers communicate with bacteria in the mouth

May 8, 2018
A new UCLA-led study provides clear evidence that cellular messengers in saliva may be able to regulate the growth of oral bacteria responsible for diseases, such as periodontitis and meningitis.

Drug-filled, 3-D printed dentures could fight off infections

April 25, 2018
Nearly two-thirds of the U.S. denture-wearing population suffer frequent fungal infections that cause inflammation, redness and swelling in the mouth.

Bacteria boost antifungal drug resistance in severe childhood tooth decay

April 25, 2018
Early childhood caries, a form of severe tooth decay affecting toddlers and preschoolers, can set children up for a lifetime of dental and health problems. The problem can be significant enough that surgery is the only effective ...

Absence of a transcription factor halts tooth development in mid-stride

April 11, 2018
Amjad Javed, Ph.D., and University of Alabama at Birmingham colleagues have found a key role in tooth development for the transcription factor Specificity protein 7, or Sp7.

Toothpaste alone does not prevent dental erosion or hypersensitivity

March 14, 2018
The rising prevalence of dental erosion and dentin hypersensitivity has led to the emergence of more toothpastes that claim to treat these problems. While no such toothpaste existed 20 years ago, today, many such brands are ...

Study: Absence of key protein, TTP, rapidly turns young bones old

March 10, 2018
The absence of a protein critical to the control of inflammation may lead to rapid and severe bone loss, according to a new University at Buffalo study.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.