Bacillus Calmette-Guerin vaccine may reduce atopic dermatitis

September 25, 2017

(HealthDay)—Bacillus Calmette-Guérin (BCG) vaccination within seven days of birth may reduce the risk of allergic diseases, including atopic dermatitis, according to a study published online Sept. 20 in Allergy.

Lisbeth Marianne Thøstesen, M.D., Ph.D., from Kolding Hospital in Denmark, and colleagues randomized newborns within seven days of birth to BCG or no BCG as part of the Danish Calmette Study (2012 to 2015). Over 13 months of follow-up, data were collected through telephone interviews and clinical examinations.

The researchers found that clinical atopic dermatitis was diagnosed in 466 of 2,052 children in the BCG group and 495 of 1,952 children in the control group (relative risk, 0.90; 95 percent confidence interval, 0.80 to 1.00). There was a significant difference in the effect of neonatal BCG vaccination between children with atopic predisposition (relative risk, 0.84; 95 percent confidence interval, 0.74 to 0.95) and children without atopic predisposition (relative risk, 1.09; 95 percent confidence interval, 0.88 to 1.37) (test of no interaction, P = 0.04).

"Among with predisposition, the number-needed-to-treat with BCG to prevent one case of was 21," the authors write.

Explore further: Efficacy of wet wrap therapy for atopic dermatitis undetermined

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Efficacy of wet wrap therapy for atopic dermatitis undetermined

November 14, 2016
(HealthDay)—Evidence that wet wrap therapy (WWT) is more effective than topical steroids for the treatment of atopic dermatitis is mixed, according to a review published online Nov. 8 in the British Journal of Dermatology.

Phthalate, paraben levels up in children with atopic dermatitis

March 21, 2017
(HealthDay)—Children aged 4 to 9 years with atopic dermatitis and with frequent use of emollients have increased urinary levels of low-molecular weight (LMW) phthalate metabolites and parabens, according to a study published ...

IgE allergy testing improves atopic dermatitis outcomes

July 6, 2017
(HealthDay)—Identification of allergens by immunoglobulin E (IgE) testing improves outcomes in atopic dermatitis, according to a study published online June 20 in the International Journal of Dermatology.

Countering atopic dermatitis immune reactions

August 4, 2017
Human leukocyte antigen (HLA)-G is a protein that interacts with specific cell receptors to inhibit immune responses. The protein is best known for its role in protecting the fetus from attack by its mother's immune system. ...

Scientists identify single-gene mutations that lead to atopic dermatitis

June 19, 2017
Researchers have identified mutations in a gene called CARD11 that lead to atopic dermatitis, or eczema, an allergic skin disease. Scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of ...

Are prebiotics or probiotics effective against dermatitis?

January 31, 2017
Evidence supporting a key role for an altered gut microbiome in the development of atopic dermatitis (AD) would suggest that the use of probiotics or prebiotics to correct microbial imbalances in the gut could help prevent ...

Recommended for you

Researchers uncover immune cell dysfunction linked to photosensitivity

August 16, 2018
Researchers at Hospital for Special Surgery (HSS) have discovered that a type of immune cell known as Langerhans appears to play an important role in photosensitivity, an immune system reaction to sunlight that can trigger ...

Chemicals found in vegetables prevent colon cancer in mice

August 14, 2018
Chemicals produced by vegetables such as kale, cabbage and broccoli could help to maintain a healthy gut and prevent colon cancer, a new study from the Francis Crick Institute shows.

Researchers artificially generate immune cells integral to creating cancer vaccines

August 14, 2018
For the first time, Mount Sinai researchers have identified a way to make large numbers of immune cells that can help prevent cancer reoccurrence, according to a study published in August in Cell Reports.

Doctors may be able to enlist a mysterious enzyme to stop internal bleeding

August 14, 2018
Blood platelets are like the sand bags of the body. Got a cut? Platelets pile in to clog the hole and stop the bleeding.

Team finds missing immune cells that could fight lethal brain tumors

August 13, 2018
Glioblastoma brain tumors can have an unusual effect on the body's immune system, often causing a dramatic drop in the number of circulating T-cells that help drive the body's defenses.

Cannabis link to relieving intestinal inflammation explained

August 13, 2018
Reports from cannabis users that the drug reduces the symptoms of inflammatory bowel disease (IBD) may finally be explained by new research from the University of Massachusetts Medical School and the University of Bath showing ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.