Cardiometabolic risk, HOMA-IR up with increasing BMI in young

Cardiometabolic risk, HOMA-IR up with increasing BMI in young

(HealthDay)—Cardiometabolic risk and homeostatic model assessment (HOMA) of insulin resistance (IR) increase with increasing body mass index (BMI) categories among children, and cardiorespiratory fitness (CRF) may attenuate the risk, according to a study published online Sept. 14 in Diabetes Care.

Christine Delisle Nyström, from the Karolinska Institutet in Stockholm, and colleagues conducted a pooled study involving cross-sectional data from three projects, with 1,247 children aged 8 to 11 years. The authors used the sum of the sex- and age-specific z scores for triglycerides, high-density lipoprotein (HDL) cholesterol, glucose, and the average of systolic and , and HOMA-IR to assess cardiometabolic risk.

The researchers identified a significant linear association between the and BMI categories (P trend ≤ 0.001), with a 0.5 standard deviation higher risk score for every incremental rise in BMI category (P < 0.001). As BMI categories rose, the risk score was attenuated by CRF, with the biggest difference seen in the most obese children; only in mild obesity was the attenuation significant (P = 0.048). Compared with obese fit children, normal-weight unfit children had a significantly lower risk score (P < 0.001); obese fit versus unfit children had a significant reduction in the risk score (P = 0.027). The results were similar for HOMA-IR.

"As BMI categories rose so did and HOMA-IR, which highlights the need for obesity prevention/treatment programs in childhood," the authors write.

Explore further

Does sleep duration affect cardiac metabolic risk in young children?

More information: Abstract/Full Text (subscription or payment may be required)
Journal information: Diabetes Care

Copyright © 2017 HealthDay. All rights reserved.

Citation: Cardiometabolic risk, HOMA-IR up with increasing BMI in young (2017, September 27) retrieved 4 December 2020 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments