Diverse neurological effects linked to anti-PD-1 therapy

September 11, 2017

(HealthDay)—Neurological complications associated with anti-programmed death 1 (PD-1) antibody treatment have a diverse phenotype, according to a study published online Sept. 5 in JAMA Neurology.

Justin C. Kao, M.B.Ch.B., from the Mayo Clinic in Rochester, Minnesota, and colleagues conducted a involving patients with development of neurological symptoms within 12 months of receiving anti-PD-1 therapy.

The researchers found that 2.9 percent of the 347 patients treated with anti-PD-1 monoclonal antibodies developed subacute onset of . Seven of these patients received pembrolizumab and three nivolumab. Neurological complications occurred after a median of 5.5 anti-PD-1 inhibitor cycles. Myopathy, varied neuropathies, cerebellar ataxia, autoimmune retinopathy, bilateral internuclear ophthalmoplegia, and headache were reported complications. Reported were axonal and demyelinating polyradiculoneuropathies, length-dependent neuropathies, and asymmetric vasculitic neuropathy.

"Neurological adverse events associated with anti-PD-1 therapy have a diverse phenotype, with more frequent neuromuscular complications," the authors write. "Prompt recognition and discontinuation of anti-PD-1 is recommended. In some cases, immune rescue treatment may be required."

One author disclosed financial ties to the pharmaceutical industry.

Explore further: Melanoma therapy tied to cutaneous adverse events

More information: Abstract/Full Text
Editorial

Related Stories

Melanoma therapy tied to cutaneous adverse events

March 16, 2016
(HealthDay)—Anti-programmed cell death (PD)-1 therapy for metastatic melanoma is associated with the development of immune-related cutaneous events, according to research published in the March issue of the Journal of the ...

Skin lesions for 29 percent with anti-TNF treatment in IBD

December 8, 2015
(HealthDay)—For patients with inflammatory bowel disease treated with anti-tumor necrosis factor (TNF) therapy, skin lesions frequently develop but rarely necessitate treatment discontinuation, according to research published ...

Transvenous pacemaker complications common, costly

August 31, 2017
(HealthDay)—The incidence of complications for single- and dual-chamber transvenous pacemakers (TVPs) is considerable, reaching about 15 and 16 percent, respectively, by three years, with high associated costs, according ...

Majority of derm clinic patients express interest in anti-aging tx

August 14, 2017
(HealthDay)—Patients are largely unfamiliar with most anti-aging treatment options, but are interested in pursuing future treatment, according to a study published online Aug. 3 in the Journal of Cosmetic Dermatology.

No advantage of ambulance over hospital anti-clot therapy for heart attack patients

August 29, 2017
In contrast to European and American guidelines that recommend pre-hospital antiplatelet therapy for heart attack patients suffering from ST-elevation myocardial infarction (STEMI), a new study presented at ESC Congress suggests ...

Responses to treatment, outcomes of autoimmune cerebellar ataxia

September 28, 2015
While autoimmune cerebellar ataxia (a loss of muscle coordination) can lead to severe disability with some patients becoming wheelchair-bound, there are factors that may help to predict better immunotherapy response and neurological ...

Recommended for you

Cognitive training helps regain a younger-working brain

January 23, 2018
Relentless cognitive decline as we age is worrisome, and it is widely thought to be an unavoidable negative aspect of normal aging. Researchers at the Center for BrainHealth at The University of Texas at Dallas, however, ...

Lifting the veil on 'valence,' brain study reveals roots of desire, dislike

January 23, 2018
The amygdala is a tiny hub of emotions where in 2016 a team led by MIT neuroscientist Kay Tye found specific populations of neurons that assign good or bad feelings, or "valence," to experience. Learning to associate pleasure ...

Your brain responses to music reveal if you're a musician or not

January 23, 2018
How your brain responds to music listening can reveal whether you have received musical training, according to new Nordic research conducted in Finland (University of Jyväskylä and AMI Center) and Denmark (Aarhus University).

New neuron-like cells allow investigation into synthesis of vital cellular components

January 22, 2018
Neuron-like cells created from a readily available cell line have allowed researchers to investigate how the human brain makes a metabolic building block essential for the survival of all living organisms. A team led by researchers ...

Finding unravels nature of cognitive inflexibility in fragile X syndrome

January 22, 2018
Mice with the genetic defect that causes fragile X syndrome (FXS) learn and remember normally, but show an inability to learn new information that contradicts what they initially learned, shows a new study by a team of neuroscientists. ...

Epilepsy linked to brain volume and thickness differences

January 22, 2018
Epilepsy is associated with thickness and volume differences in the grey matter of several brain regions, according to new research led by UCL and the Keck School of Medicine of USC.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.