Individualized SBP tx cuts risk for post-op organ dysfunction

Individualized SBP tx cuts risk for post-op organ dysfunction

(HealthDay)—Management targeting an individualized systolic blood pressure (SBP) is associated with reduced risk of organ dysfunction among patients undergoing major surgery who are at increased risk of postoperative complications, according to a study published in the Sept. 26 issue of the Journal of the American Medical Association.

Emmanuel Futier, M.D., Ph.D., from the University Clermont Auvergne in Clermont-Ferrand, France, and colleagues randomized adult at increased risk of with a preoperative acute kidney injury risk index of class III or higher undergoing lasting two hours or longer under general anesthetic to an individualized management strategy aimed at achieving SBP within 10 percent of the reference value (147 patients) or to a standard management strategy (145 patients). The primary outcome was a composite of systemic inflammation response syndrome and dysfunction of at least one of the renal, respiratory, cardiovascular, coagulation, and neurological organ systems by postoperative day seven.

The researchers found that the primary outcome event occurred in 38.1 and 51.7 percent of patients assigned to the individualized treatment group and standard treatment strategy group, respectively (relative risk, 0.73). Postoperative organ dysfunction by day 30 occurred in 46.3 and 63.4 percent of patients in the individualized treatment and standard treatment groups, respectively (adjusted hazard ratio, 0.66).

"Management targeting an individualized , compared with standard management, reduced the risk of postoperative organ dysfunction," the authors write.

Several authors disclosed financial ties to industry.

Explore further

Intensive BP control associated with increased CKD risk

More information: Abstract
Full Text

Copyright © 2017 HealthDay. All rights reserved.

Citation: Individualized SBP tx cuts risk for post-op organ dysfunction (2017, September 27) retrieved 15 December 2019 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments