Calcium intake and colorectal cancer

Calcium plays key roles in cellular signaling, proliferation and death. Previous studies exploring the relationship between dietary calcium intake and colorectal cancer have had contradictory results, perhaps due to no consideration of variation in calcium reabsorption by the kidney.

Qi Dai, M.D., Ph.D., and colleagues examined how variation in genes involved in calcium reabsorption related to the risk of colorectal adenoma (pre-cancer lesion) in patients enrolled in the Tennessee Colorectal Polyp Study. They found that variants in a sodium-calcium exchanger protein interacted with in colorectal adenoma risk.

They further found that carriers of variants in two of three calcium reabsorption genes with calcium intake above 1000 mg/day were up to 57 percent less likely to have adenomas compared to those with lower calcium intake.

The findings, reported in the October issue of Molecular Carcinogenesis, suggest a protective effect of calcium intake in individuals with certain gene variants and may provide a new approach for personalized prevention of colorectal adenoma and cancer.


Explore further

Calcium may cut risk for precancerous colon lesions in some people

More information: Jing Zhao et al. Interactions between calcium intake and polymorphisms in genes essential for calcium reabsorption and risk of colorectal neoplasia in a two-phase study, Molecular Carcinogenesis (2017). DOI: 10.1002/mc.22678
Provided by Vanderbilt University
Citation: Calcium intake and colorectal cancer (2017, October 19) retrieved 16 January 2019 from https://medicalxpress.com/news/2017-10-calcium-intake-colorectal-cancer.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more