Study identifies genetic clues to spinal stenosis

A new study published in the Journal of Orthopaedic Research indicates that certain genetic changes are linked with an increased risk of developing lumbar spinal stenosis, a narrowing of the open spaces in the lower spine that can lead to pain in the legs when individuals walk.

The results from the study, which included 469 , provide insights into the potential causes of spinal stenosis. "Our study represents a tremendous leap forward in our understanding of the condition," said senior author Dr. Dino Samartzis. "With a better understanding of the condition and the identification of genetic markers, individuals who are at increased risk can be identified early and preventative measures can be initiated. The information may also help investigators develop more novel and precision-based management options for affected patients."

Lead author Dr. Jason Cheung added, "We finally have a clearer understanding regarding the genetic and developmental background of spinal narrowing. The bony spinal canal diameter is a unique phenotype that should not be mistaken for a canal measurement at the level of the disc, where it is highly influenced by disc degeneration features."


Explore further

A new way to find out if back problems need surgery

More information: Jason Pui Yin Cheung et al, Etiology of Developmental Spinal Stenosis: a Genome-Wide Association Study, Journal of Orthopaedic Research (2017). DOI: 10.1002/jor.23746
Provided by Wiley
Citation: Study identifies genetic clues to spinal stenosis (2017, October 13) retrieved 18 September 2019 from https://medicalxpress.com/news/2017-10-genetic-clues-spinal-stenosis.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more