Process promising for on-site printing of custom-dosed meds

October 4, 2017

(HealthDay)—Small molecular medicines can be printed precisely using organic vapor jets, according to a study published online Sept. 27 in Nature Communications.

Olga Shalev, Ph.D., from the University of Michigan in Ann Arbor, and colleagues discussed the potential use of solvent-free organic vapor jets to print small molecular medicines.

The researchers found that nanostructured films of small molecular pharmaceutical ingredients could be deposited by use of solvent-free printing; these ingredients included caffeine, acetaminophen, ibuprofen, tamoxifen, BAY 11-7082, and fluorescein. Accuracy was on the scale of µg per cm². The pharmaceutical ingredients could be printed onto glass, Tegaderm, Listerine tabs, and stainless steel microneedles. Similar crystallographic order and chemistry was demonstrated by the printed films and the original powders; relative to powder-form particles, controlled, order-of-magnitude enhancements of dissolution rate were observed. In vitro treatment of breast and ovarian cancer cell cultures in aqueous media by tamoxifen and BAY 11-7082 films showed similar behavior to drugs pre-dissolved in dimethyl sulfoxide.

"The ability to deposit small molecular drugs from their pure form, as and without the use of solvents as shown here, opens an alternative approach to drug screening and manufacturing, where accurate dosage, chemical and structural stability, and processing flexibility are needed without hindering functionality," the authors write. "The technique demonstrated here also potentially enables continuous manufacturing, eliminating the need for mixing and powder preparation."

Explore further: Eli Lilly develops continuous manufacturing process for chemotherapy drug

More information: Abstract/Full Text

Related Stories

Eli Lilly develops continuous manufacturing process for chemotherapy drug

June 16, 2017
Researchers at pharmaceutical giant Eli Lilly have developed a continuous manufacturing process for a chemotherapy drug, officials with the company recently announced. In their paper published in the journal Science, the ...

Recommended for you

Drug for spinal muscular atrophy prompts ethical dilemmas, bioethicists say

December 11, 2017
When the Food and Drug Administration approved the first drug for people with spinal muscular atrophy a year ago, clinicians finally had hope for improving the lives of patients with the rare debilitating muscular disease. ...

FDA's program to speed up drug approval shaved nearly a year off the process

December 7, 2017
Speeding the pace at which potentially lifesaving drugs are brought to market was a rallying cry for Donald Trump as a candidate, and is a stated priority of his Food and Drug Administration commissioner, Dr. Scott Gottlieb. ...

Dangers of commonly prescribed painkillers highlighted in study

December 6, 2017
Commonly prescribed painkillers need to be given for shorter periods of time to reduce the risk of obesity and sleep deprivation, a new study has revealed.

Viagra goes generic: Pfizer to launch own little white pill

December 6, 2017
The little blue pill that's helped millions of men in the bedroom is turning white. Drugmaker Pfizer is launching its own cheaper generic version of Viagra rather than lose most sales when the impotence pill gets its first ...

Surgery-related opioid doses can drop dramatically without affecting patients' pain

December 6, 2017
Some surgeons might be able to prescribe a third of opioid painkiller pills that they currently give patients, and not affect their level of post-surgery pain control, a new study suggests.

Four-fold jump in deaths in opioid-driven hospitalizations

December 4, 2017
People who end up in the hospital due to an opioid-related condition are four times more likely to die now than they were in 2000, according to research led by Harvard Medical School and published in the December issue of ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.